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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4j531J4Serine/threonine-protein kinase PLK12.7.11.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4j531J4Serine/threonine-protein kinase PLK12.7.11.211.000
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.525
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.525
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.516
2yac937Serine/threonine-protein kinase PLK12.7.11.210.492
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.488
4b6l9ZPSerine/threonine-protein kinase PLK32.7.11.210.477
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.456
2owb626Serine/threonine-protein kinase PLK12.7.11.210.441