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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hseADPChaperone protein ClpB

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4hseADPChaperone protein ClpB/1.000
3cgdNADCoenzyme A disulfide reductase/0.466
2bl4NADLactaldehyde reductase1.1.1.770.464
3ii43IIDihydrolipoyl dehydrogenase1.8.1.40.460
4fd2ADPChaperone protein ClpB/0.459
4fcwADPChaperone protein ClpB/0.458
2cd8PXICytochrome P450 monooxygenase PikC/0.456
2b52D42Cyclin-dependent kinase 22.7.11.220.453
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.452
3eigMTXDihydrofolate reductase1.5.1.30.448
4hjfC2EGGDEF family protein/0.447
1qvrANPChaperone protein ClpB/0.445
2ghmLICMitogen-activated protein kinase 14/0.445
1nqoNADGlyceraldehyde-3-phosphate dehydrogenase/0.444
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.443
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.442
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.441
1f0xFADD-lactate dehydrogenase1.1.1.280.440
3cgeNDPCoenzyme A disulfide reductase/0.440