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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4g1wG1WMitogen-activated protein kinase 82.7.11.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4g1wG1WMitogen-activated protein kinase 82.7.11.241.000
4e730NRMitogen-activated protein kinase 82.7.11.240.567
4hys1BJMitogen-activated protein kinase 82.7.11.240.542
4hyu1BKMitogen-activated protein kinase 82.7.11.240.497
3kvxFMYMitogen-activated protein kinase 102.7.11.240.488
3uvqFS8Mitogen-activated protein kinase 14/0.487
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.484
4jia1K3Tyrosine-protein kinase JAK2/0.473
4c4f7CEDual specificity protein kinase TTK2.7.12.10.468
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.457
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.456
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.451
2p33J07Mitogen-activated protein kinase 102.7.11.240.449
3cgfJNFMitogen-activated protein kinase 102.7.11.240.446
2xrwANPMitogen-activated protein kinase 82.7.11.240.444
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.442
2vu3LZECyclin-dependent kinase 22.7.11.220.440
4fob0USALK tyrosine kinase receptor2.7.10.10.440