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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fl2ANPTyrosine-protein kinase SYK2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fl2ANPTyrosine-protein kinase SYK2.7.10.21.000
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.583
4k2rANPTyrosine-protein kinase ZAP-702.7.10.20.521
2ozoANPTyrosine-protein kinase ZAP-702.7.10.20.497
3orpAGSSerine/threonine protein kinase/0.459
1hckATPCyclin-dependent kinase 22.7.11.220.457
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.454
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.452
2btrU73Cyclin-dependent kinase 22.7.11.220.450
5cnnANPEpidermal growth factor receptor2.7.10.10.450
1b38ATPCyclin-dependent kinase 22.7.11.220.449
3orkAGSSerine/threonine protein kinase/0.449
4dgmAGICasein kinase II subunit alpha2.7.11.10.449
4k33ACPFibroblast growth factor receptor 32.7.10.10.449
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.448
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.446
3k5uPFQAurora kinase A2.7.11.10.446
3nynSGVG protein-coupled receptor kinase 62.7.11.160.446
3c4zADPRhodopsin kinase/0.445
3vn9ANKDual specificity mitogen-activated protein kinase kinase 62.7.12.20.444
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.443
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.442
3plsANPMacrophage-stimulating protein receptor2.7.10.10.441
1dawANPCasein kinase II subunit alpha2.7.11.10.440
1dayGNPCasein kinase II subunit alpha2.7.11.10.440
3ortAGSSerine/threonine protein kinase/0.440
4zseANPEpidermal growth factor receptor2.7.10.10.440