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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4f6w0SSCyclin-dependent kinase 82.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4f6w0SSCyclin-dependent kinase 82.7.11.221.000
4f7l0SOCyclin-dependent kinase 82.7.11.220.500
4f700STCyclin-dependent kinase 82.7.11.220.480
2ejvNADL-threonine 3-dehydrogenase/0.475
1wwkNAD307aa long hypothetical phosphoglycerate dehydrogenase/0.458
1a72PADAlcohol dehydrogenase E chain1.1.1.10.457
3h4lANPDNA mismatch repair protein PMS1/0.457
4q71FADBifunctional protein PutA/0.457
1adfTADAlcohol dehydrogenase E chain1.1.1.10.456
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.456
1bwsNDPGDP-L-fucose synthase/0.454
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.454
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.454
2v59LZKBiotin carboxylase6.3.4.140.451
1ldeNADAlcohol dehydrogenase E chain1.1.1.10.449
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.443
4q73FADBifunctional protein PutA/0.443
3b4yF42F420-dependent glucose-6-phosphate dehydrogenase/0.442
3kb6NADD-lactate dehydrogenase/0.442
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.442
1cbqRE9Cellular retinoic acid-binding protein 2/0.441
4a8v2ANMajor pollen allergen Bet v 1-J/0.441