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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4f0e0RUPoly [ADP-ribose] polymerase 152.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4f0e0RUPoly [ADP-ribose] polymerase 152.4.2.301.000
3geyP34Poly [ADP-ribose] polymerase 152.4.2.300.537
4pnmNU1Tankyrase-22.4.2.300.488
4pnrG18Tankyrase-22.4.2.300.485
4bj9UHBTankyrase-22.4.2.300.483
4bjcRPBTankyrase-22.4.2.300.482
4krs1SXTankyrase-12.4.2.300.481
3u9y09LTankyrase-22.4.2.300.480
4tjy3GNTankyrase-22.4.2.300.475
4tkg09LTankyrase-22.4.2.300.474
4j3mAJ8Tankyrase-22.4.2.300.466
2g1n1IGRenin3.4.23.150.460
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.457
1xk9P34Exotoxin A2.4.2.360.450
4bfvZVVPantothenate kinase2.7.1.330.450
3h3r14HCollagen type IV alpha-3-binding protein/0.449
3s3vTOPDihydrofolate reductase1.5.1.30.445
3wagTYDGlycosyltransferase/0.445
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.444
2zseACPPantothenate kinase2.7.1.330.444
4bfzZVZPantothenate kinase2.7.1.330.443
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.443
1g6kNADGlucose 1-dehydrogenase1.1.1.470.442
2hpvFMNFMN-dependent NADH-azoreductase1.70.441
2xuqTZ4Acetylcholinesterase3.1.1.70.441
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.440
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440