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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ejh0QACytochrome P450 2A131.14.14.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4ejh0QACytochrome P450 2A131.14.14.11.000
4ejgNCTCytochrome P450 2A131.14.14.10.595
3t3q9PLCytochrome P450 2A61.14.130.582
3t3r9PLCytochrome P450 2A61.14.130.546
3qm4PN0Cytochrome P450 2D6/0.502
3ibdCPZCytochrome P450 2B61.14.130.492
4eji0QACytochrome P450 2A131.14.14.10.482
3tk3CPZCytochrome P450 2B41.14.14.10.480
3s79ASDAromatase1.14.14.140.463
1suoCPZCytochrome P450 2B41.14.14.10.461
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.456
4j6dTESCytochrome P450 monooxygenase/0.445
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.444