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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4egh0OYHeat shock protein HSP 90-alpha

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4egh0OYHeat shock protein HSP 90-alpha/1.000
2yi66QMHeat shock protein HSP 90-alpha/0.611
2wi5ZZ5Heat shock protein HSP 90-alpha/0.597
2ye42FYHeat shock protein HSP 90-alpha/0.594
2vci2GJHeat shock protein HSP 90-alpha/0.589
2wi1ZZ2Heat shock protein HSP 90-alpha/0.583
2bsmBSMHeat shock protein HSP 90-alpha/0.576
2uwd2GGHeat shock protein HSP 90-alpha/0.564
2vcj2EQHeat shock protein HSP 90-alpha/0.561
2yecXQ0Heat shock protein HSP 90-alpha/0.554
2ye92D4Heat shock protein HSP 90-alpha/0.553
2yjwYJWHeat shock protein HSP 90-alpha/0.535
4fcq2N6Heat shock protein HSP 90-alpha/0.523
3hyz42CHeat shock protein HSP 90-alpha/0.509
1yc14BCHeat shock protein HSP 90-alpha/0.505
2ccu2D9Heat shock protein HSP 90-alpha/0.499
4awp99AHeat shock protein HSP 90-alpha/0.496
2cct2E1Heat shock protein HSP 90-alpha/0.494
4eftEFTHeat shock protein HSP 90-alpha/0.492
2yegXQGHeat shock protein HSP 90-alpha/0.490
4ipeANPTNF receptor-associated protein 1/0.488
2qg0A94Heat shock protein HSP 90-alpha/0.487
4jqlVJ6Heat shock protein HSP 90-alpha/0.485
2yi7BZ8Heat shock protein HSP 90-alpha/0.484
2wi2ZZ3Heat shock protein HSP 90-alpha/0.482
4bqjXKLHeat shock protein HSP 90-alpha/0.477
1osfKOSHeat shock protein HSP 90-alpha/0.476
4awq592Heat shock protein HSP 90-alpha/0.472
1yetGDMHeat shock protein HSP 90-alpha/0.469
3ft5MO8Heat shock protein HSP 90-alpha/0.466
4egkRDCHeat shock protein HSP 90-alpha/0.466
1yc443PHeat shock protein HSP 90-alpha/0.460
2xabVHDHeat shock protein HSP 90-alpha/0.460
1yc34BCHeat shock protein HSP 90-alpha/0.459
3ekrPY9Heat shock protein HSP 90-alpha/0.459
3ft8MOJHeat shock protein HSP 90-alpha/0.457
3omuIBDHeat shock protein 83/0.455
4bqg50QHeat shock protein HSP 90-alpha/0.454
4ivgANPTNF receptor-associated protein 1/0.454
4xclAGSHeat shock cognate 90 kDa protein/0.449
1uy9PU6Heat shock protein HSP 90-alpha/0.444
2qg2A91Heat shock protein HSP 90-alpha/0.440