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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4e2bFMNDehydrogenase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4e2bFMNDehydrogenase/1.000
4e2dFMNDehydrogenase/0.647
3atyFMNProstaglandin F2a synthase/0.643
3atzFMNProstaglandin F2a synthase/0.632
4jicFMNGTN Reductase/0.559
3f03FMNPentaerythritol tetranitrate reductase/0.543
1h63FMNPentaerythritol tetranitrate reductase/0.542
1h50FMNPentaerythritol tetranitrate reductase/0.530
3p82FMNPentaerythritol tetranitrate reductase/0.519
1vyrFMNPentaerythritol tetranitrate reductase/0.518
2abbFMNPentaerythritol tetranitrate reductase/0.518
3p74FMNPentaerythritol tetranitrate reductase/0.517
4a3uFMNNADH:flavin oxidoreductase/NADH oxidase/0.514
3p62FMNPentaerythritol tetranitrate reductase/0.512
3p67FMNPentaerythritol tetranitrate reductase/0.506
2q3rFMN12-oxophytodienoate reductase 11.3.1.420.502
4rnuFMNNADPH dehydrogenase 11.6.99.10.498
3gkaFMNN-ethylmaleimide reductase/0.493
1bwlFMNNADPH dehydrogenase 11.6.99.10.489
1h51FMNPentaerythritol tetranitrate reductase/0.487
1icsFMN12-oxophytodienoate reductase 11.3.1.420.486
1vjiFMN12-oxophytodienoate reductase 11.3.1.420.486
3p8jFMNPentaerythritol tetranitrate reductase/0.483
4tmbFMNOld yellow enzyme/0.480
3hgoFMN12-oxophytodienoate reductase 31.3.1.420.477
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.475
4m5pFMNNADPH dehydrogenase/0.471
3p84FMNPentaerythritol tetranitrate reductase/0.469
1icqFMN12-oxophytodienoate reductase 11.3.1.420.465
2hs8FMN12-oxophytodienoate reductase 31.3.1.420.464
3hl0NADMaleylacetate reductase/0.462
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.460
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.460
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
1q45FMN12-oxophytodienoate reductase 31.3.1.420.459
3hgrFMN12-oxophytodienoate reductase 11.3.1.420.459
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
3hgsFMN12-oxophytodienoate reductase 31.3.1.420.456
4h6kFMNNADPH dehydrogenase 11.6.99.10.455
3p8iFMNPentaerythritol tetranitrate reductase/0.452
4rnvFMNNADPH dehydrogenase 11.6.99.10.452
4tmcFMNOld yellow enzyme/0.452
1nvtNAPShikimate dehydrogenase (NADP(+))/0.451
2ev9NAPShikimate dehydrogenase (NADP(+))/0.451
4df2FMNNADPH dehydrogenase/0.448
1bwkFMNNADPH dehydrogenase 11.6.99.10.446
4r81FMNPredicted NADH dehydrogenase/0.445
2hs6FMN12-oxophytodienoate reductase 31.3.1.420.444
1icpFMN12-oxophytodienoate reductase 11.3.1.420.443
1oycFMNNADPH dehydrogenase 11.6.99.10.443
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.442
1nzdUPGDNA beta-glucosyltransferase/0.441
1fcbFMNCytochrome b2, mitochondrial1.1.2.30.440
3gfbNADL-threonine 3-dehydrogenase/0.440