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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dnaFADProbable glutathione reductase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4dnaFADProbable glutathione reductase/1.000
2jk6FADTrypanothione reductase/0.581
2hqmFADGlutathione reductase1.8.1.70.537
1fecFADTrypanothione reductase1.8.1.120.527
1tytFADTrypanothione reductase1.8.1.120.525
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.517
4la1FADThioredoxin glutathione reductase/0.516
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.510
1gxfFADTrypanothione reductase1.8.1.120.509
1grhFADGlutathione reductase, mitochondrial1.8.1.70.505
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.505
1febFADTrypanothione reductase1.8.1.120.502
1bzlFADTrypanothione reductase1.8.1.120.487
4nevFADTrypanothione reductase/0.486
4j56FADThioredoxin reductase 21.8.1.90.474
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.473
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.471
3grsFADGlutathione reductase, mitochondrial1.8.1.70.467
2wbaFADTrypanothione reductase1.8.1.120.462
4fx9FADCoenzyme A disulfide reductase1.8.1.140.456
1gerFADGlutathione reductase1.8.1.70.451
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.440
2x8gFADThioredoxin glutathione reductase/0.440