scPDB - Distribution of Cavity Similarity values of 4cx5 entry / Site 2

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4cx5	HW8	Nitric oxide synthase, brain	1.14.13.39

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
4cx5	HW8	Nitric oxide synthase, brain	1.14.13.39	1.000
3rqm	X2E	Nitric oxide synthase, brain	1.14.13.39	0.785
3png	8CX	Nitric oxide synthase, brain	1.14.13.39	0.754
4eux	HW1	Nitric oxide synthase, brain	1.14.13.39	0.720
3ufu	HW8	Nitric oxide synthase, brain	1.14.13.39	0.705
3pnf	8BX	Nitric oxide synthase, brain	1.14.13.39	0.699
4cx3	HW8	Nitric oxide synthase, brain	1.14.13.39	0.699
3jwt	JI5	Nitric oxide synthase, brain	1.14.13.39	0.694
3rql	X2D	Nitric oxide synthase, brain	1.14.13.39	0.658
3nlj	JRR	Nitric oxide synthase, brain	1.14.13.39	0.646
3nlz	3XD	Nitric oxide synthase, brain	1.14.13.39	0.642
4lux	QJ8	Nitric oxide synthase, brain	1.14.13.39	0.641
3jx6	JI5	Nitric oxide synthase, brain	1.14.13.39	0.630
3jx5	J14	Nitric oxide synthase, brain	1.14.13.39	0.629
3n5w	XFJ	Nitric oxide synthase, brain	1.14.13.39	0.626
4jsi	Q05	Nitric oxide synthase, brain	1.14.13.39	0.625
3jx2	JI4	Nitric oxide synthase, brain	1.14.13.39	0.621
3n62	XFJ	Nitric oxide synthase, brain	1.14.13.39	0.620
3pne	8AX	Nitric oxide synthase, brain	1.14.13.39	0.620
4imt	1EW	Nitric oxide synthase, brain	1.14.13.39	0.619
3nln	JRS	Nitric oxide synthase, brain	1.14.13.39	0.614
3rqj	Y2B	Nitric oxide synthase, brain	1.14.13.39	0.613
4cx4	HW9	Nitric oxide synthase, brain	1.14.13.39	0.608
3nlp	JSS	Nitric oxide synthase, brain	1.14.13.39	0.607
3ufq	HW5	Nitric oxide synthase, brain	1.14.13.39	0.607
3ufv	HW9	Nitric oxide synthase, brain	1.14.13.39	0.607
3n5x	XFK	Nitric oxide synthase, brain	1.14.13.39	0.605
3nly	3XC	Nitric oxide synthase, brain	1.14.13.39	0.604
3ufr	H5W	Nitric oxide synthase, brain	1.14.13.39	0.602
4k5g	Q13	Nitric oxide synthase, brain	1.14.13.39	0.602
3nny	59R	Nitric oxide synthase, brain	1.14.13.39	0.600
3svp	JK5	Nitric oxide synthase, brain	1.14.13.39	0.598
3nlq	JRR	Nitric oxide synthase, brain	1.14.13.39	0.596
3jx3	JI5	Nitric oxide synthase, brain	1.14.13.39	0.595
3ufo	HW4	Nitric oxide synthase, brain	1.14.13.39	0.594
3ufw	HW0	Nitric oxide synthase, brain	1.14.13.39	0.587
4imw	1EV	Nitric oxide synthase, brain	1.14.13.39	0.583
3rqk	X2C	Nitric oxide synthase, brain	1.14.13.39	0.581
3jx0	JI4	Nitric oxide synthase, brain	1.14.13.39	0.580
3rqm	H4B	Nitric oxide synthase, brain	1.14.13.39	0.573
3nlv	3XA	Nitric oxide synthase, brain	1.14.13.39	0.572
4jsg	Q10	Nitric oxide synthase, brain	1.14.13.39	0.572
3jws	JI4	Nitric oxide synthase, brain	1.14.13.39	0.571
3svq	JK4	Nitric oxide synthase, brain	1.14.13.39	0.566
4jsf	QJ4	Nitric oxide synthase, brain	1.14.13.39	0.563
3png	H4B	Nitric oxide synthase, brain	1.14.13.39	0.560
3n5y	XFL	Nitric oxide synthase, brain	1.14.13.39	0.552
3nlw	3XF	Nitric oxide synthase, brain	1.14.13.39	0.552
3n5v	XFH	Nitric oxide synthase, brain	1.14.13.39	0.551
3jx4	J11	Nitric oxide synthase, brain	1.14.13.39	0.550
3ufs	HW6	Nitric oxide synthase, brain	1.14.13.39	0.549
3nnz	59W	Nitric oxide synthase, brain	1.14.13.39	0.548
3tym	08R	Nitric oxide synthase, brain	1.14.13.39	0.541
4k5d	1Q6	Nitric oxide synthase, brain	1.14.13.39	0.541
3n65	XFJ	Nitric oxide synthase, brain	1.14.13.39	0.540
3uft	HW7	Nitric oxide synthase, brain	1.14.13.39	0.539
3nlr	JRS	Nitric oxide synthase, brain	1.14.13.39	0.538
3n5z	XFM	Nitric oxide synthase, brain	1.14.13.39	0.536
3n61	XFJ	Nitric oxide synthase, brain	1.14.13.39	0.532
3tyl	AXW	Nitric oxide synthase, brain	1.14.13.39	0.531
3ufu	H4B	Nitric oxide synthase, brain	1.14.13.39	0.531
4jsj	QJ7	Nitric oxide synthase, brain	1.14.13.39	0.530
4k5e	1Q7	Nitric oxide synthase, brain	1.14.13.39	0.526
4k5f	Q14	Nitric oxide synthase, brain	1.14.13.39	0.526
3jwu	J11	Nitric oxide synthase, brain	1.14.13.39	0.525
4imu	1ET	Nitric oxide synthase, brain	1.14.13.39	0.524
3jwt	H4B	Nitric oxide synthase, brain	1.14.13.39	0.523
3nlo	JSR	Nitric oxide synthase, brain	1.14.13.39	0.517
2hx4	4HX	Nitric oxide synthase, brain	1.14.13.39	0.516
3ufp	H4W	Nitric oxide synthase, brain	1.14.13.39	0.516
1zzq	DP9	Nitric oxide synthase, brain	1.14.13.39	0.512
3pnf	H4B	Nitric oxide synthase, brain	1.14.13.39	0.512
1rs6	DP2	Nitric oxide synthase, brain	1.14.13.39	0.508
3nlk	JSS	Nitric oxide synthase, brain	1.14.13.39	0.507
3b3p	JI7	Nitric oxide synthase, brain	1.14.13.39	0.505
1zzu	DP1	Nitric oxide synthase, brain	1.14.13.39	0.504
4cx3	H4B	Nitric oxide synthase, brain	1.14.13.39	0.503
3rqj	H4B	Nitric oxide synthase, brain	1.14.13.39	0.502
3b3o	JI3	Nitric oxide synthase, brain	1.14.13.39	0.501
4lux	H4B	Nitric oxide synthase, brain	1.14.13.39	0.501
3nlj	H4B	Nitric oxide synthase, brain	1.14.13.39	0.499
2hx4	H4B	Nitric oxide synthase, brain	1.14.13.39	0.497
3ufq	H4B	Nitric oxide synthase, brain	1.14.13.39	0.492
1zzr	DP9	Nitric oxide synthase, brain	1.14.13.39	0.490
3jx3	H4B	Nitric oxide synthase, brain	1.14.13.39	0.490
4fvz	H4B	Nitric oxide synthase, brain	1.14.13.39	0.486
3nln	H4B	Nitric oxide synthase, brain	1.14.13.39	0.484
3nlz	H4B	Nitric oxide synthase, brain	1.14.13.39	0.482
3jx5	H4B	Nitric oxide synthase, brain	1.14.13.39	0.478
3nnz	H4B	Nitric oxide synthase, brain	1.14.13.39	0.475
1p6j	DP9	Nitric oxide synthase, brain	1.14.13.39	0.472
4cx5	H4B	Nitric oxide synthase, brain	1.14.13.39	0.472
4jsi	H4B	Nitric oxide synthase, brain	1.14.13.39	0.466
3n66	XFN	Nitric oxide synthase, brain	1.14.13.39	0.462
3n63	XFN	Nitric oxide synthase, brain	1.14.13.39	0.459
3nly	H4B	Nitric oxide synthase, brain	1.14.13.39	0.458
3ufv	H4B	Nitric oxide synthase, brain	1.14.13.39	0.457
4jsh	Q15	Nitric oxide synthase, brain	1.14.13.39	0.455
3pne	H4B	Nitric oxide synthase, brain	1.14.13.39	0.454
3nlp	H4B	Nitric oxide synthase, brain	1.14.13.39	0.453
4imt	H4B	Nitric oxide synthase, brain	1.14.13.39	0.453
3n60	XFN	Nitric oxide synthase, brain	1.14.13.39	0.452
3jx2	H4B	Nitric oxide synthase, brain	1.14.13.39	0.449
3b3n	H4B	Nitric oxide synthase, brain	1.14.13.39	0.448
3rql	H4B	Nitric oxide synthase, brain	1.14.13.39	0.448
4jsg	H4B	Nitric oxide synthase, brain	1.14.13.39	0.448
1k2t	H4B	Nitric oxide synthase, brain	1.14.13.39	0.447
1k2u	H4B	Nitric oxide synthase, brain	1.14.13.39	0.447
4eux	H4B	Nitric oxide synthase, brain	1.14.13.39	0.445
3b3o	H4B	Nitric oxide synthase, brain	1.14.13.39	0.442
3n5y	H4B	Nitric oxide synthase, brain	1.14.13.39	0.442