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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bjbP34Tankyrase-22.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4bjbP34Tankyrase-22.4.2.301.000
4pnmNU1Tankyrase-22.4.2.300.572
4bjcRPBTankyrase-22.4.2.300.561
4bj9UHBTankyrase-22.4.2.300.551
4tjy3GNTankyrase-22.4.2.300.549
4k4eK4ETankyrase-12.4.2.300.535
3u9y09LTankyrase-22.4.2.300.516
4tkg09LTankyrase-22.4.2.300.507
4li61XOTankyrase-12.4.2.300.503
4li81XQTankyrase-12.4.2.300.503
4hyf1AKTankyrase-22.4.2.300.498
4pnrG18Tankyrase-22.4.2.300.496
4msk2C8Tankyrase-12.4.2.300.494
4mt92D6Tankyrase-12.4.2.300.488
4i9i1DYTankyrase-12.4.2.300.486
4krs1SXTankyrase-12.4.2.300.480
4n4v2GYTankyrase-12.4.2.300.477
4li71XPTankyrase-12.4.2.300.472
4j3mAJ8Tankyrase-22.4.2.300.469
1xk9P34Exotoxin A2.4.2.360.468
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.464
4msg2C6Tankyrase-12.4.2.300.456
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.455
2zitNADExotoxin A2.4.2.360.452
5dsyUHBPoly [ADP-ribose] polymerase 22.4.2.300.442
3b8hNADExotoxin A2.4.2.360.440