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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3vquO22Dual specificity protein kinase TTK2.7.12.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3vquO22Dual specificity protein kinase TTK2.7.12.11.000
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.525
4c4g7RODual specificity protein kinase TTK2.7.12.10.471
4c4f7CEDual specificity protein kinase TTK2.7.12.10.470
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.467
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.457
4c4jX21Dual specificity protein kinase TTK2.7.12.10.457
3l8p0CEAngiopoietin-1 receptor2.7.10.10.454
4bi1ZO6Dual specificity protein kinase TTK2.7.12.10.454
2w05FRTCyclin-dependent kinase 22.7.11.220.449
3ttjJBIMitogen-activated protein kinase 102.7.11.240.449
2b1pAIZMitogen-activated protein kinase 102.7.11.240.448
4i22IREEpidermal growth factor receptor2.7.10.10.448
3gubGUBDeath-associated protein kinase 12.7.11.10.446
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.446
2gtk208Peroxisome proliferator-activated receptor gamma/0.445
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4erwSTUCyclin-dependent kinase 22.7.11.220.441
5dr9SKEAurora kinase A2.7.11.10.440