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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3u9dATPActin, alpha skeletal muscle

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3u9dATPActin, alpha skeletal muscle/1.000
3m6gATPActin, alpha skeletal muscle/0.557
1h1vATPActin, alpha skeletal muscle/0.531
4jhdANPActin-5C/0.530
4k42ADPActin, alpha skeletal muscle/0.523
5ce3ATPActin/0.522
3mn6ATPActin-5C/0.519
1ijjATPActin, alpha skeletal muscle/0.518
3ffkATPActin, alpha skeletal muscle/0.512
4pl8ATPActin, alpha skeletal muscle/0.508
2q36ATPActin, alpha skeletal muscle/0.506
4pkhADPActin, alpha skeletal muscle/0.497
1c0fATPMajor actin/0.495
2v51ATPActin, alpha skeletal muscle/0.494
1nmdATPMajor actin/0.491
4m63ATPActin-5C/0.490
3m1fATPActin, alpha skeletal muscle/0.488
3mn9ATPActin-5C/0.488
4pkgATPActin, alpha skeletal muscle/0.485
1rgiATPActin, alpha skeletal muscle/0.482
1lotATPActin, alpha skeletal muscle/0.481
4cbxATPActin-2/0.480
4rwtANPActin-5C/0.479
1s22ATPActin, alpha skeletal muscle/0.474
3tu5ATPActin, alpha skeletal muscle/0.470
3a5mATPMajor actin/0.468
1kxpATPActin, alpha skeletal muscle/0.457
1t44ATPActin, alpha skeletal muscle/0.454
1mduATPActin, alpha skeletal muscle/0.453
1nm1ATPMajor actin/0.453
4pkiATPActin, alpha skeletal muscle/0.451
1qz5ATPActin, alpha skeletal muscle/0.447
3u4lATPActin, cytoplasmic 1/0.442
3w3dATPActin, gamma-enteric smooth muscle/0.441