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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3tgpGNPGTPase HRas

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3tgpGNPGTPase HRas/1.000
4xvqGNPGTPase HRas/0.666
2rggGNPGTPase HRas/0.620
4hdqGNPRas-related protein Rap-1b/0.620
4xvrGNPGTPase HRas/0.610
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.561
3pitGNPRas-related protein M-Ras/0.545
2fe4GDPRas-related protein Rab-6B/0.541
4l9sGDPGTPase HRas/0.535
2cl6CAGGTPase HRas/0.534
3kkoGNPRas-related protein M-Ras/0.530
3kkqGDPRas-related protein M-Ras/0.530
4lpkGDPGTPase KRas/0.524
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.520
1zc4GNPRas-related protein Ral-A/0.518
1x1rGDPRas-related protein M-Ras/0.514
3qbtGNPRas-related protein Rab-8A/0.514
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.512
4wa7GDPGTPase KRas/0.509
3cphGDPRas-related protein SEC4/0.506
3ddcGNPGTPase HRas/0.505
4epwGDPGTPase KRas/0.504
1lfdGNPGTPase HRas/0.503
2ce2GDPGTPase HRas/0.503
3lbhGNPGTPase HRas/0.503
2rgeGNPGTPase HRas/0.502
1cxzGSPTransforming protein RhoA/0.501
1z2aGDPRas-related protein Rab-23/0.499
4o2rGDPGTP-binding protein Rheb/0.497
3k9lGNPGTPase HRas/0.496
4l8gGDPGTPase KRas/0.495
3i3sGNPGTPase HRas/0.494
3k8yGNPGTPase HRas/0.493
4lrwGDPGTPase KRas/0.493
4lv6GDPGTPase KRas/0.493
1xtrGNPGTP-binding protein Rheb/0.492
3v4fGNPGTPase HRas/0.491
4q03GDPGTPase KRas/0.491
1zc3GNPRas-related protein Ral-A/0.490
4q02GDPGTPase KRas/0.489
3oesGNPGTPase RhebL1/0.486
3oivGNPGTPase HRas/0.486
4nyjGNPGTPase HRas/0.486
4tq9GDPGTPase KRas/0.485
1yu9GNPRas-related protein Rab-4A/0.484
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.483
2q3fGNPRas-related GTP-binding protein D/0.482
3lbnGNPGTPase HRas/0.482
2fg5GNPRas-related protein Rab-31/0.480
2gcpGSPRho-related GTP-binding protein RhoC/0.480
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.480
3x1zGNPRas-related protein Rap-1b/0.480
4dsnGCPGTPase KRas/0.480
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.479
4dsuGDPGTPase KRas/0.479
2msdGNPMHC class I alpha chain/0.478
2mscGDPMHC class I alpha chain/0.477
2bmeGNPRas-related protein Rab-4A/0.476
1a2bGSPTransforming protein RhoA/0.475
4nyiGNPGTPase HRas/0.475
1xtsGTPGTP-binding protein Rheb/0.474
4dltGNPGTPase HRas/0.474
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.473
2rgcGNPGTPase HRas/0.473
3a58GNPGTP-binding protein RHO1/0.473
3mjhGTPRas-related protein Rab-5A/0.473
1gwnGTPRho-related GTP-binding protein RhoE/0.472
4epxGDPGTPase KRas/0.471
4obeGDPGTPase KRas/0.471
1n6lGTPRas-related protein Rab-5A/0.470
1zbdGTPRas-related protein Rab-3A/0.470
3kz1GSPTransforming protein RhoA/0.470
4qxaGTPRas-related protein Rab-9A/0.470
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.468
2c5lGTPGTPase HRas/0.466
3vhxGTPADP-ribosylation factor 6/0.466
4ql3GDPGTPase KRas/0.466
1yzqGNPRas-related protein Rab-6A/0.465
3eg5GNPCell division control protein 42 homolog/0.465
3e5hGNPRas-related protein Rab-28/0.464
4kvgGTPRas-related protein Rap-1A/0.464
4ldjGDPGTPase KRas/0.464
1m7bGTPRho-related GTP-binding protein RhoE/0.463
1g17GNPRas-related protein SEC4/0.462
1ky2GNPGTP-binding protein YPT7/0.462
3oiwGNPGTPase HRas/0.462
1g16GDPRas-related protein SEC4/0.460
3rs4GNPGTPase HRas/0.459
1am4GNPCell division control protein 42 homolog/0.458
4hdoGNPRas-related protein Rap-1b/0.458
4q71FADBifunctional protein PutA/0.458
4uj3GNPRas-related protein Rab-11A/0.458
1mvsDTMDihydrofolate reductase1.5.1.30.456
4gojGNPADP-ribosylation factor-like protein 3/0.454
3qlsNDPDihydrofolate reductase1.5.1.30.453
1pq944BOxysterols receptor LXR-beta/0.452
4g0nGNPGTPase HRas/0.452
3lbiGNPGTPase HRas/0.451
3x1wGDPRas-related protein Rap-1b/0.451
5difGNPGTP-binding nuclear protein Ran/0.451
3oiuGNPGTPase HRas/0.450
1diuBDMDihydrofolate reductase1.5.1.30.449
4dlzGNPGTPase HRas/0.449
3ekuCY9Actin-5C/0.448
4js0GNPCell division control protein 42 homolog/0.448
5b2zGNPGTPase HRas/0.448
1rx8NAPDihydrofolate reductase1.5.1.30.447
1t91GTPRas-related protein Rab-7a/0.447
4cidANPEH domain-containing protein 2/0.447
5hpyGDPTransforming protein RhoA/0.447
3l8yGNPGTPase HRas/0.446
1oixGDPRas-related protein Rab-11A/0.445
2ok7FADFerredoxin--NADP reductase, apicoplast/0.445
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
3gxoMQAMitomycin biosynthesis 6-O-methyltransferase/0.445
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.444
5esoTDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.444
1gsfEAAGlutathione S-transferase A12.5.1.180.443
1zd9GDPADP-ribosylation factor-like protein 8A/0.443
1a72PADAlcohol dehydrogenase E chain1.1.1.10.442
3bbpGTPRas-related protein Rab-6A/0.442
4obuPLPPyridoxal-dependent decarboxylase domain protein/0.442
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
3w3zGTPGTP-binding nuclear protein Ran/0.441
4dlxGNPGTPase HRas/0.441
4q72FADBifunctional protein PutA/0.441
1s0xC3SNuclear receptor ROR-alpha/0.440
2clsGTPRho-related GTP-binding protein Rho6/0.440
4l4fCAMCamphor 5-monooxygenase1.14.15.10.440
5dhaGNPGTP-binding nuclear protein Ran/0.440
5hi6MTXDihydrofolate reductase/0.440