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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3smkCW714-3-3 protein sigma

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3smkCW714-3-3 protein sigma/1.000
3e6yCW114-3-3-like protein C/0.573
4ihl1F514-3-3 protein zeta/delta/0.517
2o98FSC14-3-3-like protein C/0.516
5li5THR_ALA_ASN_PRO_SEPKLTH0G14146p/0.498
5d3fFSC14-3-3 protein zeta/delta/0.490
2hk9NAPShikimate dehydrogenase (NADP(+))/0.474
2cy0NAPShikimate dehydrogenase (NADP(+))/0.468
3cppCAMCamphor 5-monooxygenase1.14.15.10.462
4v2gITCTetracycline repressor protein class D/0.455
2lfoGCHFatty acid-binding protein, liver/0.454
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.454
4e5f0N7Polymerase acidic protein/0.454
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.452
2xpwOTCTetracycline repressor protein class D/0.450
3gueUPGUTP-glucose-1-phosphate uridylyltransferase 2, putative/0.449
2y3sTIRTamL/0.448
1fmjRTLRetinol dehydratase/0.447
4q72FADBifunctional protein PutA/0.445
4kugNAD3-hydroxybutyryl-CoA dehydrogenase/0.444
3cvuFADRE11660p/0.443
6cp4CAMCamphor 5-monooxygenase1.14.15.10.442
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.441
4oqyNDP(S)-imine reductase/0.441