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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3r6pA8SAbscisic acid receptor PYL10

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3r6pA8SAbscisic acid receptor PYL10/1.000
3oquA8SAbscisic acid receptor PYL9/0.527
3njoP2MAbscisic acid receptor PYR1/0.525
3nefPYVAbscisic acid receptor PYL1/0.518
3nmpPYVAbscisic acid receptor PYL2/0.513
4dscA8SAbscisic acid receptor PYL3/0.513
3negPYVAbscisic acid receptor PYL1/0.509
3w9rA8SAbscisic acid receptor PYL9/0.488
3nj0PYVAbscisic acid receptor PYL2/0.483
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.483
1og5SWFCytochrome P450 2C9/0.482
3ns2PYVAbscisic acid receptor PYL2/0.481
3njoPYVAbscisic acid receptor PYR1/0.477
3ujlA8SAbscisic acid receptor PYL2/0.476
4oicA8SBet v I allergen-like/0.472
1phgMYTCamphor 5-monooxygenase1.14.15.10.470
2qblCAMCamphor 5-monooxygenase1.14.15.10.469
4jdaA9SAbscisic acid receptor PYL3/0.469
2m56CAMCamphor 5-monooxygenase1.14.15.10.467
2qo6CHDFatty acid-binding protein 10-A, liver basic/0.465
3wrlCAMCamphor 5-monooxygenase1.14.15.10.464
2qd5CHDFerrochelatase, mitochondrial4.99.1.10.462
4la7A1OAbscisic acid receptor PYL2/0.462
4lg5A1OAbscisic acid receptor PYL2/0.462
3eej53RUncharacterized protein/0.461
4ds8A8SAbscisic acid receptor PYL3/0.458
3kdiA8SAbscisic acid receptor PYL2/0.457
1fpqSAMIsoliquiritigenin 2'-O-methyltransferase/0.456
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.455
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.455
4cdmFO1Deoxyribodipyrimidine photolyase/0.455
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.455
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.454
3ls8AJZPhosphatidylinositol 3-kinase catalytic subunit type 32.7.1.1370.454
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.452
5cp4CAMCamphor 5-monooxygenase1.14.15.10.452
1iwiCAMCamphor 5-monooxygenase1.14.15.10.451
3nmnPYVAbscisic acid receptor PYL1/0.451
1enyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
2qboCAMCamphor 5-monooxygenase1.14.15.10.450
4lgaA2OAbscisic acid receptor PYL2/0.450
1dz6CAMCamphor 5-monooxygenase1.14.15.10.449
1rk3VDXVitamin D3 receptor/0.449
3nmhPYVAbscisic acid receptor PYL2/0.449
4cd2FOLDihydrofolate reductase1.5.1.30.449
4dsbA8SAbscisic acid receptor PYL3/0.449
4l4aCAMCamphor 5-monooxygenase1.14.15.10.449
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.448
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2jn3JN3Fatty acid-binding protein, liver/0.447
2zawCAMCamphor 5-monooxygenase1.14.15.10.447
3cyz9ODPheromone-binding protein ASP1/0.447
1u2gAPRNAD(P) transhydrogenase subunit alpha part 11.6.1.20.446
3c3dFO12-phospho-L-lactate transferase/0.446
3cz09ODPheromone-binding protein ASP1/0.446
3h18PMSEsterase/lipase/0.446
3k3kA8SAbscisic acid receptor PYR1/0.446
1fm4DXCMajor pollen allergen Bet v 1-L/0.445
1rkhVD2Vitamin D3 receptor/0.445
3gwfFADCyclohexanone monooxygenase/0.445
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
3gwfNAPCyclohexanone monooxygenase/0.444
4l4bCAMCamphor 5-monooxygenase1.14.15.10.444
1klkPMDDihydrofolate reductase1.5.1.30.443
1txiTX5Vitamin D3 receptor/0.443
2hb8MVDVitamin D3 receptor/0.443
3zvuA8SAbscisic acid receptor PYR1/0.443
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4iteTEYVitamin D3 receptor/0.443
4l49CAMCamphor 5-monooxygenase1.14.15.10.443
1fp2HMOIsoflavone-7-O-methyltransferase 82.1.1.1500.442
1iwjCAMCamphor 5-monooxygenase1.14.15.10.442
2po7CHDFerrochelatase, mitochondrial4.99.1.10.442
3qly55VUncharacterized protein/0.442
3vt7VDXVitamin D3 receptor/0.442
3vt9YI4Vitamin D3 receptor/0.442
4fhi0S4Vitamin D3 receptor A/0.442
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.442
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
1enzNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
2a1nCAMCamphor 5-monooxygenase1.14.15.10.441
3vrwYS5Vitamin D3 receptor/0.441
4cp4CAMCamphor 5-monooxygenase1.14.15.10.441
4g1z0VPVitamin D3 receptor A/0.441
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
1drbMTXDihydrofolate reductase1.5.1.30.440
1rkgVD1Vitamin D3 receptor/0.440
3kb3A8SAbscisic acid receptor PYL2/0.440
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440
3wrmCAMCamphor 5-monooxygenase1.14.15.10.440