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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qfaFADThioredoxin reductase 1, cytoplasmic1.8.1.9

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3qfaFADThioredoxin reductase 1, cytoplasmic1.8.1.91.000
4j57FADThioredoxin reductase 21.8.1.90.564
2hqmFADGlutathione reductase1.8.1.70.524
2tprFADTrypanothione reductase1.8.1.120.514
2x8hFADThioredoxin glutathione reductase/0.513
1fecFADTrypanothione reductase1.8.1.120.503
1tytFADTrypanothione reductase1.8.1.120.503
2x8gFADThioredoxin glutathione reductase/0.501
4b1bFADThioredoxin reductase1.8.1.90.501
2wbaFADTrypanothione reductase1.8.1.120.474
1dncFADGlutathione reductase, mitochondrial1.8.1.70.468
4dnaFADProbable glutathione reductase/0.467
1gxfFADTrypanothione reductase1.8.1.120.453