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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3p7aP7AMitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3p7aP7AMitogen-activated protein kinase 14/1.000
1kv2B96Mitogen-activated protein kinase 14/0.644
3o8uBMUMitogen-activated protein kinase 14/0.643
3p7bP7BMitogen-activated protein kinase 14/0.631
3uvr06FMitogen-activated protein kinase 14/0.620
3p7cP7CMitogen-activated protein kinase 14/0.608
2yisYISMitogen-activated protein kinase 14/0.605
3hv6R39Mitogen-activated protein kinase 14/0.581
1kv1BMUMitogen-activated protein kinase 14/0.573
3gcuR48Mitogen-activated protein kinase 14/0.538
4l8mF46Mitogen-activated protein kinase 14/0.525
4eh90OQMitogen-activated protein kinase 14/0.518
1wbsLI2Mitogen-activated protein kinase 14/0.515
1wbtWBTMitogen-activated protein kinase 14/0.511
1wbvLI3Mitogen-activated protein kinase 14/0.507
3nnwEDDMitogen-activated protein kinase 14/0.502
3nnxEDDMitogen-activated protein kinase 14/0.502
3npcB96Mitogen-activated protein kinase 92.7.11.240.500
3nnuEDBMitogen-activated protein kinase 14/0.494
3p5kP5KMitogen-activated protein kinase 14/0.486
3d83GK6Mitogen-activated protein kinase 14/0.484
3hv4L51Mitogen-activated protein kinase 14/0.480
1wbnL09Mitogen-activated protein kinase 14/0.479
3lffZ83Mitogen-activated protein kinase 14/0.478
3gcvSS6Mitogen-activated protein kinase 14/0.475
2e2b406Tyrosine-protein kinase ABL12.7.10.20.467
1wbwLI4Mitogen-activated protein kinase 14/0.457
3wzeBAXVascular endothelial growth factor receptor 22.7.10.10.457
2yiwYIWMitogen-activated protein kinase 14/0.456
3hv71AUMitogen-activated protein kinase 14/0.456
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
1rfqLARActin, alpha skeletal muscle/0.448
3vhe42QVascular endothelial growth factor receptor 22.7.10.10.448
4fp9SAM5-methylcytosine rRNA methyltransferase NSUN42.1.10.448
1w82L10Mitogen-activated protein kinase 14/0.447
2hiw7MPTyrosine-protein kinase ABL12.7.10.20.444
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.444
3sgx0FWDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.444
3r7yZ04Cyclin-dependent kinase 22.7.11.220.443
5hidB1ESerine/threonine-protein kinase B-raf2.7.11.10.442
3dfcANPDeath-associated protein kinase 12.7.11.10.440