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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3k981RCHeat shock protein HSP 90-alpha

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3k981RCHeat shock protein HSP 90-alpha/1.000
3k99PFTHeat shock protein HSP 90-alpha/0.516
3hekBD0Heat shock protein HSP 90-alpha/0.510
3r4pFU7Heat shock protein HSP 90-alpha/0.502
3rlq3RQHeat shock protein HSP 90-alpha/0.496
2werRDCATP-dependent molecular chaperone HSP82/0.494
2xhtC0YHeat shock protein HSP 90-alpha/0.487
1am1ADPATP-dependent molecular chaperone HSP82/0.481
4bqjXKLHeat shock protein HSP 90-alpha/0.480
2wepADPATP-dependent molecular chaperone HSP82/0.476
3r4nFU5Heat shock protein HSP 90-alpha/0.473
1uyePU9Heat shock protein HSP 90-alpha/0.470
2byi2DDHeat shock protein HSP 90-alpha/0.466
1u0zRDCEndoplasmin/0.465
1u2oNECEndoplasmin/0.463
4fcr0TMHeat shock protein HSP 90-alpha/0.463
1yc34BCHeat shock protein HSP 90-alpha/0.460
1yszNECEndoplasmin/0.460
3k974CDHeat shock protein HSP 90-alpha/0.459
1u0yPA7Endoplasmin/0.455
2xjjL81Heat shock protein HSP 90-alpha/0.455
2xabVHDHeat shock protein HSP 90-alpha/0.454
2breKJ2ATP-dependent molecular chaperone HSP82/0.450
2exlGDMEndoplasmin/0.449
2iwuNP5ATP-dependent molecular chaperone HSP82/0.449
3hhu819Heat shock protein HSP 90-alpha/0.449
3vhaVHAHeat shock protein HSP 90-alpha/0.449
4jqlVJ6Heat shock protein HSP 90-alpha/0.447
4ce3L4VATP-dependent molecular chaperone HSP82/0.444
1qy8RDIEndoplasmin/0.441