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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3dawATPActin, alpha skeletal muscle

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3dawATPActin, alpha skeletal muscle/1.000
4jhdANPActin-5C/0.593
3tu5ATPActin, alpha skeletal muscle/0.577
1rgiATPActin, alpha skeletal muscle/0.564
3mn6ATPActin-5C/0.559
4k42ADPActin, alpha skeletal muscle/0.559
4k41ATPActin, alpha skeletal muscle/0.557
1eqyATPActin, alpha skeletal muscle/0.555
1s22ATPActin, alpha skeletal muscle/0.555
4pl8ATPActin, alpha skeletal muscle/0.552
1t44ATPActin, alpha skeletal muscle/0.545
3el2ATPActin-5C/0.545
3u9dATPActin, alpha skeletal muscle/0.542
4pkgATPActin, alpha skeletal muscle/0.538
1qz5ATPActin, alpha skeletal muscle/0.537
4k43ADPActin, alpha skeletal muscle/0.533
3mn7ATPActin-5C/0.524
3eksATPActin-5C/0.523
2q36ATPActin, alpha skeletal muscle/0.521
1nm1ATPMajor actin/0.516
3a5mATPMajor actin/0.516
4cbxATPActin-2/0.516
4ci6ATPActin/0.515
2p9kATPActin-related protein 2/0.509
2q97ATPActin, alpha skeletal muscle/0.507
1mduATPActin, alpha skeletal muscle/0.497
1yxqATPActin, alpha skeletal muscle/0.488
1nmdATPMajor actin/0.485
2oanATPActin, cytoplasmic 1/0.470
1dejATPMajor actin/0.452
1nlvATPMajor actin/0.445