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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3dagFEG5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3dagFEG5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.21.000
3dafFEG5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.681
3f46I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.679
3h65I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.653
3f47I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.587
4gkvNADAlcohol dehydrogenase, propanol-preferring1.1.1.10.451
2e9cB75Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.447
4ocvANPAminoglycoside phosphotransferase/0.446