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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.21.000
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.560
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
4hge15VTyrosine-protein kinase JAK2/0.474
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.472
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.470
4fv6E57Mitogen-activated protein kinase 12.7.11.240.459
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.456
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.455
2j0m4STFocal adhesion kinase 12.7.10.20.452
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.450
1yvj4STTyrosine-protein kinase JAK32.7.10.20.449
3zewSTUEphrin type-B receptor 42.7.10.10.447
3a62STURibosomal protein S6 kinase beta-12.7.11.10.446
3i60E86Mitogen-activated protein kinase 12.7.11.240.443
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.441
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.440
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.440