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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2zb0GK3Mitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2zb0GK3Mitogen-activated protein kinase 14/1.000
2zazGK1Mitogen-activated protein kinase 14/0.603
3l8xN4DMitogen-activated protein kinase 14/0.571
2gfsPQBMitogen-activated protein kinase 14/0.569
3gfeP37Mitogen-activated protein kinase 14/0.564
3iphG11Mitogen-activated protein kinase 14/0.562
1ouy094Mitogen-activated protein kinase 14/0.552
2zb1GK4Mitogen-activated protein kinase 14/0.543
3s4qNK0Mitogen-activated protein kinase 14/0.542
4aa5NQBMitogen-activated protein kinase 14/0.537
3uvqFS8Mitogen-activated protein kinase 14/0.533
3hllI45Mitogen-activated protein kinase 14/0.531
1bl6SB6Mitogen-activated protein kinase 14/0.529
3ha85JZMitogen-activated protein kinase 14/0.524
3mpaSB2Mitogen-activated protein kinase 14/0.522
3hp552PMitogen-activated protein kinase 14/0.521
1zyjBI5Mitogen-activated protein kinase 14/0.514
3fmh533Mitogen-activated protein kinase 14/0.513
4nka2K7Fibroblast growth factor receptor 1/0.513
2rg6287Mitogen-activated protein kinase 14/0.512
1di9MSQMitogen-activated protein kinase 14/0.508
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.507
3fmn530Mitogen-activated protein kinase 14/0.507
3fskRO6Mitogen-activated protein kinase 14/0.507
3roc29AMitogen-activated protein kinase 14/0.506
3uibSB2Putative mitogen-activated protein kinase/0.505
3itzP66Mitogen-activated protein kinase 14/0.503
1w84L12Mitogen-activated protein kinase 14/0.498
3flzFLZMitogen-activated protein kinase 14/0.498
3mpt1GKMitogen-activated protein kinase 14/0.497
1ouk084Mitogen-activated protein kinase 14/0.496
3fl4FL4Mitogen-activated protein kinase 14/0.495
3fklFKLMitogen-activated protein kinase 14/0.494
3gc7B45Mitogen-activated protein kinase 14/0.494
3fsfFSSMitogen-activated protein kinase 14/0.492
2qd9LGFMitogen-activated protein kinase 14/0.491
3flsFLSMitogen-activated protein kinase 14/0.491
3bv2P38Mitogen-activated protein kinase 14/0.490
3dt1P40Mitogen-activated protein kinase 14/0.490
3uvp048Mitogen-activated protein kinase 14/0.489
4eh60ONMitogen-activated protein kinase 14/0.488
2balPQAMitogen-activated protein kinase 14/0.486
1ywrLI9Mitogen-activated protein kinase 14/0.485
3fmkFMKMitogen-activated protein kinase 14/0.483
3lfa1N1Mitogen-activated protein kinase 14/0.483
3fln3FNMitogen-activated protein kinase 14/0.482
1zzlTZYMitogen-activated protein kinase 14/0.481
3fmlFMLMitogen-activated protein kinase 14/0.481
3fi4FI4Mitogen-activated protein kinase 14/0.480
3flwFLWMitogen-activated protein kinase 14/0.480
3flyFLYMitogen-activated protein kinase 14/0.480
4eh50OMMitogen-activated protein kinase 14/0.480
4aacAAVMitogen-activated protein kinase 14/0.479
2rg5279Mitogen-activated protein kinase 14/0.478
3zsh469Mitogen-activated protein kinase 14/0.478
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.477
3hub469Mitogen-activated protein kinase 14/0.476
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.476
1ove358Mitogen-activated protein kinase 14/0.475
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.475
3gc9B45Mitogen-activated protein kinase 112.7.11.240.473
3hl7I47Mitogen-activated protein kinase 14/0.472
3fc152PMitogen-activated protein kinase 14/0.471
4kiq1RAMitogen-activated protein kinase 14/0.471
2nu9COASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.470
3bx5304Mitogen-activated protein kinase 14/0.470
4eym0RXMitogen-activated protein kinase 132.7.11.240.470
4aa4QC0Mitogen-activated protein kinase 14/0.468
3ac1KZITyrosine-protein kinase Lck2.7.10.20.467
4kip1R9Mitogen-activated protein kinase 14/0.467
2izrBRKCasein kinase I isoform gamma-32.7.11.10.466
3mvl38PMitogen-activated protein kinase 14/0.465
3fkoFKOMitogen-activated protein kinase 14/0.464
3nww3NWMitogen-activated protein kinase 14/0.464
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.464
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.463
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.462
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.461
3oc1BMUMitogen-activated protein kinase 14/0.461
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.461
2ghmLICMitogen-activated protein kinase 14/0.460
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.460
3o8tBMUMitogen-activated protein kinase 14/0.459
4kin1M8Mitogen-activated protein kinase 14/0.459
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.459
1dssNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.458
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.458
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.458
2q3kMUWGag-Pol polyprotein/0.457
1m17AQ4Epidermal growth factor receptor2.7.10.10.456
3vjoANPEpidermal growth factor receptor2.7.10.10.456
3ocgOCGMitogen-activated protein kinase 14/0.455
4dlj6RGMitogen-activated protein kinase 14/0.454
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.453
3hv3R49Mitogen-activated protein kinase 14/0.453
2of4979Tyrosine-protein kinase Lck2.7.10.20.452
2xyeCXGGag-Pol polyprotein/0.452
1k6pXN3Gag-Pol polyprotein3.4.23.160.451
1t3r017Gag-Pol polyprotein3.4.23.160.450
3fmmXI2Mitogen-activated protein kinase 14/0.450
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.450
1bl7SB4Mitogen-activated protein kinase 14/0.449
1k6cMK1Gag-Pol polyprotein3.4.23.160.449
1m7qDQOMitogen-activated protein kinase 14/0.449
4h4xFADBiphenyl dioxygenase ferredoxin reductase subunit/0.449
2yixYIXMitogen-activated protein kinase 14/0.448
3hucG97Mitogen-activated protein kinase 14/0.448
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.448
3w2o03PEpidermal growth factor receptor2.7.10.10.448
2itwITQEpidermal growth factor receptor2.7.10.10.447
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.447
3bv3P39Mitogen-activated protein kinase 14/0.447
3mvm39PMitogen-activated protein kinase 14/0.446
3pg3DG7Mitogen-activated protein kinase 14/0.446
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
2v51LABActin, alpha skeletal muscle/0.445
4djqM86Pol polyprotein/0.445
5k2cZMAAdenosine receptor A2a/0.445
1jvsNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.444
1ohr1UNV-1 PROTEASE protein/0.444
2itqITQEpidermal growth factor receptor2.7.10.10.444
3ac2KSETyrosine-protein kinase Lck2.7.10.20.444
3acjKSSTyrosine-protein kinase Lck2.7.10.20.444
4nxvGDPMitochondrial dynamics protein MID51/0.444
1k6tXN1Gag-Pol polyprotein3.4.23.160.443
2ewaSB2Mitogen-activated protein kinase 14/0.442
2zm4KSMTyrosine-protein kinase Lck2.7.10.20.442
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3e92G6AMitogen-activated protein kinase 14/0.442
3gstGPRGlutathione S-transferase Mu 12.5.1.180.442
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.442
2ituITQEpidermal growth factor receptor2.7.10.10.441
3rinI2OMitogen-activated protein kinase 14/0.441
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.441
4j1tNADNAD/NADP transhydrogenase alpha subunit 1/0.441
4lopSB4Mitogen-activated protein kinase 14/0.441
2j4dMHFCryptochrome DASH, chloroplastic/mitochondrial/0.440
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.440
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.440