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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.11.000
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.644
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.643
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.631
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.623
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.579
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.570
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.534
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.520
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.515
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.514
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.498
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.454
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.450
4a9tA9TSerine/threonine-protein kinase Chk22.7.11.10.449
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.446
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.446
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.445
4jbpYPHAurora kinase A2.7.11.10.445
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.444
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.442
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.442
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.440