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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2x6o2TCTetracycline repressor protein class D

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2x6o2TCTetracycline repressor protein class D/1.000
1orkATCTetracycline repressor protein class D/0.601
4v2gITCTetracycline repressor protein class D/0.595
5fkmTDCTetracycline repressor protein class D/0.580
2x9dITCTetracycline repressor protein class D/0.579
4b3aTACTetracycline repressor protein class D/0.571
2xpvMIYTetracycline repressor protein class D/0.568
2tctCTCTetracycline repressor protein class D/0.567
2fj1CTCTetracycline repressor protein class D/0.560
4auxXTCTetracycline repressor protein class D/0.560
2o7oDXTTetracycline repressor protein class D/0.553
2vkeTACTetracycline repressor protein class D/0.549
2xpuTDCTetracycline repressor protein class D/0.536
2trtTACTetracycline repressor protein class D/0.531
4d7mTDCTetracycline repressor protein class D/0.529
4abzT1CTetracycline repressor protein class D/0.526
2xrlDXTTetracycline repressor protein class D/0.525
5fklTDCTetracycline repressor protein class D/0.519
2xb5I7TTetracycline repressor protein class D/0.515
2xpwOTCTetracycline repressor protein class D/0.515
4b1rITCTetracycline repressor protein class D/0.505
5fknTDCTetracycline repressor protein class D/0.505
4v2gCTCTetracycline repressor protein class D/0.501
4ac0MIYTetracycline repressor protein class B from transposon Tn10/0.479
2ignFADPyranose 2-oxidase/0.458
3tvuB37Acetyl-CoA carboxylase/0.458
3tz3B36Acetyl-CoA carboxylase/0.456
3u33FADPutative acyl-CoA dehydrogenase AidB1.3.990.452
2vprTDCTetracycline repressor protein class H/0.446
2qbuSAHPrecorrin-2 methyltransferase/0.442
1kkq471Peroxisome proliferator-activated receptor alpha/0.440
5fkkTDCTetracycline repressor protein class D/0.440