sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2wog | ZZD | Kinesin-like protein KIF11 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2wog | ZZD | Kinesin-like protein KIF11 | / | 1.000 | |
| 3ken | ZZD | Kinesin-like protein KIF11 | / | 0.595 | |
| 2q2z | MKK | Kinesin-like protein KIF11 | / | 0.590 | |
| 4bbg | V02 | Kinesin-like protein KIF11 | / | 0.586 | |
| 2x2r | X2O | Kinesin-like protein KIF11 | / | 0.581 | |
| 2g1q | N9H | Kinesin-like protein KIF11 | / | 0.573 | |
| 2x7e | X7E | Kinesin-like protein KIF11 | / | 0.569 | |
| 1q0b | NAT | Kinesin-like protein KIF11 | / | 0.565 | |
| 4a51 | DQ8 | Kinesin-like protein KIF11 | / | 0.560 | |
| 2fme | 3QC | Kinesin-like protein KIF11 | / | 0.559 | |
| 2xae | 2XA | Kinesin-like protein KIF11 | / | 0.555 | |
| 2x7d | EGB | Kinesin-like protein KIF11 | / | 0.551 | |
| 2ieh | MOY | Kinesin-like protein KIF11 | / | 0.546 | |
| 2gm1 | 2AZ | Kinesin-like protein KIF11 | / | 0.545 | |
| 1x88 | NAT | Kinesin-like protein KIF11 | / | 0.537 | |
| 3k3b | L31 | Kinesin-like protein KIF11 | / | 0.519 | |
| 4a5y | G7X | Kinesin-like protein KIF11 | / | 0.512 | |
| 3k5e | K5E | Kinesin-like protein KIF11 | / | 0.508 | |
| 2x7c | KZ9 | Kinesin-like protein KIF11 | / | 0.492 | |
| 4as7 | 6LX | Kinesin-like protein KIF11 | / | 0.489 | |
| 1e8w | QUE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.465 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.463 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.459 | |
| 3jvh | HHV | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.458 | |
| 4ans | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.458 | |
| 2bxe | 1FL | Serum albumin | / | 0.454 | |
| 1fvt | 106 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 2iw8 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 4anq | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.450 | |
| 3zew | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.448 | |
| 4qys | PLR | Tryptophan synthase beta chain 2 | 4.2.1.20 | 0.448 | |
| 4fic | 0UL | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.447 | |
| 4ysw | NAI | Xanthine dehydrogenase/oxidase | / | 0.447 | |
| 4z35 | ON9 | Lysophosphatidic acid receptor 1 | / | 0.446 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 1qnf | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.443 | |
| 2yfx | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.443 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.443 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.442 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.440 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 4l2i | FAD | Electron transfer flavoprotein alpha/beta-subunit | / | 0.440 | |
| 4lg5 | A1O | Abscisic acid receptor PYL2 | / | 0.440 |