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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vwpNDPGlucose 1-dehydrogenase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2vwpNDPGlucose 1-dehydrogenase/1.000
2vwqNAPGlucose 1-dehydrogenase/0.705
2b5vNAPGlucose 1-dehydrogenase/0.635
1pl8NADSorbitol dehydrogenase1.1.1.140.488
2vwhNAPGlucose 1-dehydrogenase/0.471
3r1sX73Cyclin-dependent kinase 22.7.11.220.466
3r7uX96Cyclin-dependent kinase 22.7.11.220.459
3zewSTUEphrin type-B receptor 42.7.10.10.454
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.454
4ez50RSCyclin-dependent kinase 62.7.11.220.451
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.450
4ejmNAPPutative zinc-binding dehydrogenase/0.448
4y95746Tyrosine-protein kinase/0.448
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
4kbk1QGCasein kinase I isoform delta2.7.11.10.447
2briANPUridylate kinase2.7.4.220.445
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.445
2vr1ATFBiotin carboxylase6.3.4.140.444
3mdvCL6Cholesterol 24-hydroxylase/0.444
1c6zROCProtease/0.443
2a1nCAMCamphor 5-monooxygenase1.14.15.10.443
2iw84SPCyclin-dependent kinase 22.7.11.220.443
3qrtX14Cyclin-dependent kinase 22.7.11.220.443
4cp4CAMCamphor 5-monooxygenase1.14.15.10.443
1gebCAMCamphor 5-monooxygenase1.14.15.10.442
2btsU32Cyclin-dependent kinase 22.7.11.220.442
3gnqNADGlyceraldehyde-3-phosphate dehydrogenase/0.441
3u9eCOALmo1369 protein/0.440