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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2rgu356Dipeptidyl peptidase 4

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2rgu356Dipeptidyl peptidase 4/1.000
4g1f0WGDipeptidyl peptidase 4/0.582
3opmLUIDipeptidyl peptidase 4/0.571
3ccc7ACDipeptidyl peptidase 4/0.558
3g0gRUMDipeptidyl peptidase 4/0.536
3f8sPF2Dipeptidyl peptidase 4/0.532
3qbjNXZDipeptidyl peptidase 4/0.529
3g0dXIHDipeptidyl peptidase 4/0.526
3vjkM51Dipeptidyl peptidase 4/0.525
2aj8SC3Dipeptidyl peptidase 4/0.520
3g0bT22Dipeptidyl peptidase 4/0.518
4a5sN7FDipeptidyl peptidase 4/0.514
2oaeAILDipeptidyl peptidase 4/0.510
4ffw715Dipeptidyl peptidase 4/0.502
3vjlW94Dipeptidyl peptidase 4/0.484
3ccbB2YDipeptidyl peptidase 4/0.478
3h3r14HCollagen type IV alpha-3-binding protein/0.450
4a802ANMajor pollen allergen Bet v 1-A/0.449
4rxrDCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.448
3h3qH13Collagen type IV alpha-3-binding protein/0.446
4a862ANMajor pollen allergen Bet v 1-A/0.445
2xuoTZ4Acetylcholinesterase3.1.1.70.443
3fui812Leukotriene A-4 hydrolase3.3.2.60.441
2iyfERYOleandomycin glycosyltransferase2.4.10.440