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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2rc4ACOHistone acetyltransferase KAT6A

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2rc4ACOHistone acetyltransferase KAT6A/1.000
3to6LYS_CMCHistone acetyltransferase ESA1/0.615
2ozuACOHistone acetyltransferase KAT6A/0.614
1mjaCOAHistone acetyltransferase ESA1/0.611
1mjbACOHistone acetyltransferase ESA1/0.598
1fy7COAHistone acetyltransferase ESA1/0.590
1mj9COAHistone acetyltransferase ESA1/0.582
2ou2ACOHistone acetyltransferase KAT5/0.552
2y0mACOHistone acetyltransferase KAT8/0.546
2givACOHistone acetyltransferase KAT8/0.534
1p0hCOAMycothiol acetyltransferase2.3.1.1890.475
2dteNAIGlucose 1-dehydrogenase related protein/0.468
3b70NAPEnoyl reductase LovC10.465
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.465
2ym1FADPhenylacetone monooxygenase1.14.13.920.457
1ae1NAPTropinone reductase 1/0.454
3l9hEMQKinesin-like protein KIF11/0.451
3b6zCO7Enoyl reductase LovC10.448
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.448
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.448
1w6hTITPlasmepsin-23.4.23.390.447
3u33FADPutative acyl-CoA dehydrogenase AidB1.3.990.447
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.447
3lqfNADGalactitol dehydrogenase/0.446
1xe65FPPlasmepsin-23.4.23.390.445
2fj1CTCTetracycline repressor protein class D/0.444
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.444
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.443
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.443
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.443
5jscFADPutative acyl-CoA dehydrogenase/0.443
1eq2NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.442
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.442
3toxNAPPutative oxidoreductase/0.442
1ipeNDPTropinone reductase 21.1.1.2360.441
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
3dmeFADPutative conserved exported protein/0.441
3uyk0CXProbable NDP-rhamnosyltransferase/0.441