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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pulACPMethylthioribose kinase2.7.1.100

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2pulACPMethylthioribose kinase2.7.1.1001.000
2punACPMethylthioribose kinase2.7.1.1000.607
2olcADPMethylthioribose kinase2.7.1.1000.581
2pupADPMethylthioribose kinase2.7.1.1000.551
2puiADPMethylthioribose kinase2.7.1.1000.549
3igoANPCalmodulin-domain protein kinase 1, putative/0.467
4icyFADPgaE/0.461
3qlxQLRUncharacterized protein/0.457
4yduADPtRNA N6-adenosine threonylcarbamoyltransferase/0.456
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.455
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.450
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
3eej53RUncharacterized protein/0.447
4jia1K3Tyrosine-protein kinase JAK2/0.447
2j9gANPBiotin carboxylase6.3.4.140.446
1wvxBD4Death-associated protein kinase 12.7.11.10.445
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
2etm7PYFocal adhesion kinase 12.7.10.20.444
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.444
5auwQUEDeath-associated protein kinase 12.7.11.10.441
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.440
4fob0USALK tyrosine kinase receptor2.7.10.10.440
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.440
4qmlANPSerine/threonine-protein kinase 242.7.11.10.440