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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.21.000
1d3hA26Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.540
1d3gBREDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.520
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.507
1uuoBRFDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.458
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.457
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.453
3zkyWT4Isopenicillin N synthase1.21.3.10.449
3tmz06XCytochrome P450 2B41.14.14.10.445
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.445
5jlaNADPutative short-chain dehydrogenase/reductase/0.445
2q5g1FAPeroxisome proliferator-activated receptor delta/0.444
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.444
3icrCOACoenzyme A disulfide reductase/0.444
3t2zFADSulfide-quinone reductase/0.444
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.443
3t2kFADSulfide-quinone reductase/0.442
2wesFADTryptophan 5-halogenase/0.441
4ryvZEAProtein LlR18A/0.440