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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pgtGPRGlutathione S-transferase P2.5.1.18

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2pgtGPRGlutathione S-transferase P2.5.1.181.000
1aqv0HGGlutathione S-transferase P2.5.1.180.609
1aqxGTDGlutathione S-transferase P2.5.1.180.601
3gusN11Glutathione S-transferase P2.5.1.180.600
3csjCBLGlutathione S-transferase P2.5.1.180.593
2a2sGSNGlutathione S-transferase P2.5.1.180.586
9gssGTXGlutathione S-transferase P2.5.1.180.568
3pgtGBXGlutathione S-transferase P2.5.1.180.559
3n9jEAAGlutathione S-transferase P2.5.1.180.557
2oa7GTXGlutathione S-transferase P 12.5.1.180.554
3ie3N11Glutathione S-transferase P2.5.1.180.554
2j9hGTXGlutathione S-transferase P2.5.1.180.552
3o76GTBGlutathione S-transferase P 12.5.1.180.551
2oadGTBGlutathione S-transferase P 12.5.1.180.546
3dgqEAAGlutathione S-transferase P2.5.1.180.534
2glrGTXGlutathione S-transferase P 12.5.1.180.525
2oacGTBGlutathione S-transferase P 12.5.1.180.482
2po3T4K4-dehydrase/0.471
2j3qTFLAcetylcholinesterase3.1.1.70.465
2r5nTPPTransketolase 1/0.465
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.461
4bfzZVZPantothenate kinase2.7.1.330.460
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.459
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
4jlm1NNDeoxycytidine kinase2.7.1.740.458
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.456
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.454
1dx6GNTAcetylcholinesterase3.1.1.70.453
4rnwFMNNADPH dehydrogenase 11.6.99.10.451
2dvlFADAcyl-CoA dehydrogenase/0.450
2iyaZIOOleandomycin glycosyltransferase/0.450
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.449
3oagLPQRenin3.4.23.150.448
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.448
3dufR1TPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.446
3dufR1TPyruvate dehydrogenase E1 component subunit beta1.2.4.10.446
2g1o2IGRenin3.4.23.150.445
2g8yNADHydroxycarboxylate dehydrogenase B/0.445
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3rsv3RSBeta-secretase 13.4.23.460.445
5kgpACOPredicted acetyltransferase/0.445
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3l6jZ90Alr2278 protein/0.444
3m30COMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.444
3m30COMMethyl-coenzyme M reductase I subunit beta2.8.4.10.444
1mtcGPRGlutathione S-transferase Mu 12.5.1.180.443
4ms1381Gamma-aminobutyric acid type B receptor subunit 1/0.443
2whqHI6Acetylcholinesterase3.1.1.70.442
3pqbVGPPutative oxidoreductase/0.442
1qoqIGPTryptophan synthase alpha chain/0.440
4iae1DXAlr2278 protein/0.440
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.440