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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.9

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.91.000
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.553
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.548
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.544
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.535
1febFADTrypanothione reductase1.8.1.120.488
2r9zFADGlutathione amide reductase/0.486
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.478
4j56FADThioredoxin reductase 21.8.1.90.477
1grhFADGlutathione reductase, mitochondrial1.8.1.70.472
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.467
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.466
1greFADGlutathione reductase, mitochondrial1.8.1.70.465
1grgFADGlutathione reductase, mitochondrial1.8.1.70.464
1gerFADGlutathione reductase1.8.1.70.463
3grsFADGlutathione reductase, mitochondrial1.8.1.70.461
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.457
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.456
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.452
1feaFADTrypanothione reductase1.8.1.120.440