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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2iuuADPDNA translocase FtsK

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2iuuADPDNA translocase FtsK/1.000
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.480
1kkq471Peroxisome proliferator-activated receptor alpha/0.471
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.464
4fmxCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.463
3tm0ANPAminoglycoside 3'-phosphotransferase2.7.1.950.460
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.459
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.456
3ef5DGTProbable pyrophosphohydrolase/0.455
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.455
4ejh0QACytochrome P450 2A131.14.14.10.453
2znnS44Peroxisome proliferator-activated receptor alpha/0.452
3mtwM3RXaa-Pro dipeptidase, putative/0.452
3t3r9PLCytochrome P450 2A61.14.130.450
2w9hTOPDihydrofolate reductase1.5.1.30.449
2znq401Peroxisome proliferator-activated receptor delta/0.449
1nyxDRFPeroxisome proliferator-activated receptor gamma/0.448
1zeoC01Peroxisome proliferator-activated receptor gamma/0.448
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.448
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.446
1k7l544Peroxisome proliferator-activated receptor alpha/0.445
1suoCPZCytochrome P450 2B41.14.14.10.445
1knuYPAPeroxisome proliferator-activated receptor gamma/0.444
3a20FMNFMN-binding protein/0.441