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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2i1vADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.105

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2i1vADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1051.000
3qpvADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1050.633
2dwpACP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1050.604
4ma4ADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1050.601
2axnADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3/0.587
1k6mAGS6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 12.7.1.1050.578
2bifANP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.539
1bifAGS6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.529
2x7hPFNProstaglandin reductase 310.468
1nzdUPGDNA beta-glucosyltransferase/0.461
1nzfUPGDNA beta-glucosyltransferase/0.455
5kj1PFBAlcohol dehydrogenase E chain1.1.1.10.448
4enhFVXCholesterol 24-hydroxylase/0.445