scPDB - Distribution of Cavity Similarity values of 2hvo entry / Site 1

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2hvo	ZST	Aldose reductase	1.1.1.21

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
2hvo	ZST	Aldose reductase	1.1.1.21	1.000
2hvn	ZST	Aldose reductase	1.1.1.21	0.686
2fz8	ZST	Aldose reductase	1.1.1.21	0.652
2pdi	ZST	Aldose reductase	1.1.1.21	0.640
2pdg	47D	Aldose reductase	1.1.1.21	0.607
3m64	393	Aldose reductase	1.1.1.21	0.605
3ghr	LDT	Aldose reductase	1.1.1.21	0.601
3ghs	LDT	Aldose reductase	1.1.1.21	0.597
2dv0	ZST	Aldose reductase	1.1.1.21	0.596
3ghu	LDT	Aldose reductase	1.1.1.21	0.591
2pdf	ZST	Aldose reductase	1.1.1.21	0.586
1z3n	3NA	Aldose reductase	1.1.1.21	0.585
2dux	ZST	Aldose reductase	1.1.1.21	0.581
3ght	LDT	Aldose reductase	1.1.1.21	0.573
1us0	LDT	Aldose reductase	1.1.1.21	0.572
2pdb	ZST	Aldose reductase	1.1.1.21	0.572
3g5e	Q74	Aldose reductase	1.1.1.21	0.570
2pdx	ZST	Aldose reductase	1.1.1.21	0.567
2i17	LDT	Aldose reductase	1.1.1.21	0.566
2pdh	47D	Aldose reductase	1.1.1.21	0.564
2duz	ZST	Aldose reductase	1.1.1.21	0.562
3mc5	393	Aldose reductase	1.1.1.21	0.560
3mb9	ZST	Aldose reductase	1.1.1.21	0.557
2pdm	ZST	Aldose reductase	1.1.1.21	0.553
3ld5	LDT	Aldose reductase	1.1.1.21	0.553
2hv5	ZST	Aldose reductase	1.1.1.21	0.552
3lz5	LDT	Aldose reductase	1.1.1.21	0.552
2fz9	ZST	Aldose reductase	1.1.1.21	0.550
2pzn	393	Aldose reductase	1.1.1.21	0.550
2pd5	ZST	Aldose reductase	1.1.1.21	0.547
3m0i	ZST	Aldose reductase	1.1.1.21	0.547
2pdn	47D	Aldose reductase	1.1.1.21	0.544
3len	ZST	Aldose reductase	1.1.1.21	0.542
4yu1	53N	Aldose reductase	1.1.1.21	0.542
2pdj	393	Aldose reductase	1.1.1.21	0.540
1pwl	BFI	Aldose reductase	1.1.1.21	0.532
2ikj	393	Aldose reductase	1.1.1.21	0.532
4gca	2X9	Aldose reductase	1.1.1.21	0.532
2qxw	LDT	Aldose reductase	1.1.1.21	0.525
2i16	LDT	Aldose reductase	1.1.1.21	0.523
3t42	3T4	Aldose reductase	1.1.1.21	0.520
2pdl	TOL	Aldose reductase	1.1.1.21	0.518
2pdu	393	Aldose reductase	1.1.1.21	0.514
1frb	ZST	Aldose reductase-related protein 2	/	0.513
3lbo	LDT	Aldose reductase	1.1.1.21	0.511
1zua	TOL	Aldo-keto reductase family 1 member B10	1.1.1	0.510
2pdp	393	Aldose reductase	1.1.1.21	0.509
3m4h	388	Aldose reductase	1.1.1.21	0.509
2pdc	393	Aldose reductase	1.1.1.21	0.501
2fzd	TOL	Aldose reductase	1.1.1.21	0.500
2ikh	LIT	Aldose reductase	1.1.1.21	0.495
3lql	LDT	Aldose reductase	1.1.1.21	0.485
1t41	ID5	Aldose reductase	1.1.1.21	0.482
1iei	ZES	Aldose reductase	1.1.1.21	0.479
1eko	I84	Aldose reductase	1.1.1.21	0.469
2inz	OHP	Aldose reductase	1.1.1.21	0.467
1el3	I84	Aldose reductase	1.1.1.21	0.466
2pdq	47D	Aldose reductase	1.1.1.21	0.461
2iki	388	Aldose reductase	1.1.1.21	0.458
2iqd	LPA	Aldose reductase	1.1.1.21	0.458
1x1b	SAH	C-20 methyltransferase	/	0.451
1z89	62P	Aldose reductase	1.1.1.21	0.448
3wav	DWV	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	3.1.4.39	0.447
1t40	ID5	Aldose reductase	1.1.1.21	0.446
2f38	15M	Aldo-keto reductase family 1 member C3	/	0.446
2j9f	THV	2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial	1.2.4.4	0.444
2j9f	THV	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial	1.2.4.4	0.444
2nvc	ITA	Aldose reductase	1.1.1.21	0.440
3af1	GDP	Pantothenate kinase	2.7.1.33	0.440