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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2hndNVPGag-Pol polyprotein2.7.7.49

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2hndNVPGag-Pol polyprotein2.7.7.491.000
1fk9EFZGag-Pol polyprotein2.7.7.490.564
1s9eADBGag-Pol polyprotein2.7.7.490.557
4i7fNVEGag-Pol polyprotein2.7.7.490.553
1revTB9Gag-Pol polyprotein2.7.7.490.525
1c1bGCAGag-Pol polyprotein2.7.7.490.518
1tktH12Gag-Pol polyprotein2.7.7.490.508
1ikxPNUGag-Pol polyprotein2.7.7.490.505
1tkzH16Gag-Pol polyprotein2.7.7.490.501
3ffi3OBGag-Pol polyprotein2.7.7.490.492
1rt2TNKGag-Pol polyprotein2.7.7.490.490
1hnvTBOGag-Pol polyprotein2.7.7.490.486
1ikwEFZGag-Pol polyprotein2.7.7.490.482
3i0rRT3Gag-Pol polyprotein2.7.7.490.482
1ikvEFZGag-Pol polyprotein2.7.7.490.480
2ze2T27Gag-Pol polyprotein2.7.7.490.476
1klmSPPGag-Pol polyprotein2.7.7.490.472
2vg5NNCGag-Pol polyprotein2.7.7.490.471
2vg7NNIGag-Pol polyprotein2.7.7.490.471
3juhANPCasein kinase II subunit alpha2.7.11.10.469
4kko1REGag-Pol polyprotein2.7.7.490.467
1tl1H18Gag-Pol polyprotein2.7.7.490.465
4bgq38RCyclin-dependent kinase-like 52.7.11.220.465
3megT27Gag-Pol polyprotein2.7.7.490.463
1rt4UC1Gag-Pol polyprotein2.7.7.490.461
1hpzAAPGag-Pol polyprotein2.7.7.490.459
3eb0DRKUncharacterized protein/0.459
3is9AC7Gag-Pol polyprotein2.7.7.490.458
1tl3H20Gag-Pol polyprotein2.7.7.490.457
2opqHBQGag-Pol polyprotein2.7.7.490.456
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.456
2hnzPC0Gag-Pol polyprotein2.7.7.490.455
2fvdLIACyclin-dependent kinase 22.7.11.220.454
2gr1FADFerredoxin reductase/0.453
3meeT27Gag-Pol polyprotein2.7.7.490.453
4ko0JLJGag-Pol polyprotein2.7.7.490.453
1vruAAPGag-Pol polyprotein2.7.7.490.451
2rf2MRXGag-Pol polyprotein2.7.7.490.451
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.450
3pe2E1BCasein kinase II subunit alpha2.7.11.10.450
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.448
2zd1T27Gag-Pol polyprotein2.7.7.490.447
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.447
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.444
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.444
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.444
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.444
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.443
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.443
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.442
1s1wUC1Gag-Pol polyprotein2.7.7.490.441