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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2henADPEphrin type-B receptor 22.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2henADPEphrin type-B receptor 22.7.10.11.000
2qoqANPEphrin type-A receptor 32.7.10.10.615
2qo7ANPEphrin type-A receptor 32.7.10.10.586
2qocANPEphrin type-A receptor 32.7.10.10.501
3zewSTUEphrin type-B receptor 42.7.10.10.486
2ijmATPFocal adhesion kinase 12.7.10.20.484
4k8aK8AFocal adhesion kinase 12.7.10.20.476
4gk4L90Ephrin type-A receptor 32.7.10.10.471
3c4wATPRhodopsin kinase/0.465
2xvdAS6Ephrin type-B receptor 42.7.10.10.464
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.463
2j0lANPFocal adhesion kinase 12.7.10.20.463
4qnyANPMitogen activated protein kinase, putative/0.462
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.459
2qo9ANPEphrin type-A receptor 32.7.10.10.452
4c3pACPAurora kinase A2.7.11.10.452
2x9fX9FEphrin type-B receptor 42.7.10.10.441