Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ftoTMPThymidylate synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2ftoTMPThymidylate synthase/1.000
2ftoCB3Thymidylate synthase/0.882
3bhrTHGThymidylate synthase/0.605
3bgxTMPThymidylate synthase/0.587
3bgxMEFThymidylate synthase/0.581
1tysDHFThymidylate synthase/0.566
1tysTMPThymidylate synthase/0.555
4knzCB3Thymidylate synthase/0.555
4ez8DHFThymidylate synthase2.1.1.450.547
1tduDURThymidylate synthase/0.546
1fwmCB3Thymidylate synthase/0.545
1tduCB3Thymidylate synthase/0.543
3bhlTHGThymidylate synthase/0.534
4iskUMPThymidylate synthase/0.534
4gevCB3Thymidylate synthase/0.530
1dduCB3Thymidylate synthase/0.516
1dduDDUThymidylate synthase/0.514
4fogC2FThymidylate synthase ThyA/0.514
2vf0F89Thymidylate synthase/0.511
1f4fTP3Thymidylate synthase/0.501
4o7uTHFThymidylate synthase/0.489
4einNOHThymidylate synthase2.1.1.450.482
1f28UMPThymidylate synthase2.1.1.450.476
1an5CB3Thymidylate synthase/0.475
4eilUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.470
4foxUMPThymidylate synthase ThyA/0.469
1f4gTP4Thymidylate synthase/0.464
1njbUMPThymidylate synthase/0.452
2g89UMPThymidylate synthase/0.449