sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2eh4 | SAH | Diphthine synthase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2eh4 | SAH | Diphthine synthase | / | 1.000 | |
| 2e07 | SAH | Diphthine synthase | / | 0.861 | |
| 2p9d | SAH | Diphthine synthase | / | 0.860 | |
| 1wng | SAH | Diphthine synthase | / | 0.853 | |
| 2huq | SAH | Diphthine synthase | / | 0.853 | |
| 2pca | SAH | Diphthine synthase | / | 0.849 | |
| 2huv | SAH | Diphthine synthase | / | 0.840 | |
| 2ejj | SAH | Diphthine synthase | / | 0.819 | |
| 2owg | SAH | Diphthine synthase | / | 0.819 | |
| 2dsh | SAH | Diphthine synthase | / | 0.796 | |
| 2e4n | SAH | Diphthine synthase | / | 0.786 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.781 | |
| 2el0 | SAH | Diphthine synthase | / | 0.779 | |
| 2dxx | SAH | Diphthine synthase | / | 0.776 | |
| 2p6i | SAH | Diphthine synthase | / | 0.755 | |
| 2z6r | SAH | Diphthine synthase | / | 0.755 | |
| 2pb5 | SAH | Diphthine synthase | / | 0.754 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.751 | |
| 2dv5 | SAH | Diphthine synthase | / | 0.746 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.741 | |
| 2pck | SAH | Diphthine synthase | / | 0.734 | |
| 2p5c | SAH | Diphthine synthase | / | 0.722 | |
| 2el3 | SAH | Diphthine synthase | / | 0.720 | |
| 2e8r | SAH | Diphthine synthase | / | 0.719 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.717 | |
| 2e8q | SAH | Diphthine synthase | / | 0.716 | |
| 2e17 | SAH | Diphthine synthase | / | 0.712 | |
| 2ek3 | SAH | Diphthine synthase | / | 0.708 | |
| 2eld | SAH | Diphthine synthase | / | 0.708 | |
| 2pch | SAH | Diphthine synthase | / | 0.708 | |
| 2ek4 | SAH | Diphthine synthase | / | 0.697 | |
| 2ek2 | SAH | Diphthine synthase | / | 0.694 | |
| 2hux | SAH | Diphthine synthase | / | 0.691 | |
| 2dxw | SAH | Diphthine synthase | / | 0.689 | |
| 2owu | SAH | Diphthine synthase | / | 0.688 | |
| 2e15 | SAH | Diphthine synthase | / | 0.686 | |
| 2eeq | SAH | Diphthine synthase | / | 0.684 | |
| 2dv7 | SAH | Diphthine synthase | / | 0.683 | |
| 2e7r | SAH | Diphthine synthase | / | 0.683 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.683 | |
| 2dsg | SAH | Diphthine synthase | / | 0.677 | |
| 2dsi | SAH | Diphthine synthase | / | 0.672 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.668 | |
| 1vce | SAH | Diphthine synthase | / | 0.664 | |
| 2pcg | SAH | Diphthine synthase | / | 0.664 | |
| 2eni | SAH | Diphthine synthase | / | 0.662 | |
| 2dxv | SAH | Diphthine synthase | / | 0.658 | |
| 2p5f | SAH | Diphthine synthase | / | 0.653 | |
| 2e08 | SAH | Diphthine synthase | / | 0.652 | |
| 2owk | SAH | Diphthine synthase | / | 0.650 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.646 | |
| 2en5 | SAH | Diphthine synthase | / | 0.644 | |
| 2e8s | SAH | Diphthine synthase | / | 0.643 | |
| 2hut | SAH | Diphthine synthase | / | 0.643 | |
| 2pci | SAH | Diphthine synthase | / | 0.640 | |
| 2egb | SAH | Diphthine synthase | / | 0.639 | |
| 2ek7 | SAH | Diphthine synthase | / | 0.633 | |
| 2emr | SAH | Diphthine synthase | / | 0.624 | |
| 2p6l | SAH | Diphthine synthase | / | 0.622 | |
| 2p6k | SAH | Diphthine synthase | / | 0.621 | |
| 2ele | SAH | Diphthine synthase | / | 0.619 | |
| 2e8h | SAH | Diphthine synthase | / | 0.617 | |
| 2ejk | SAH | Diphthine synthase | / | 0.616 | |
| 2eh2 | SAH | Diphthine synthase | / | 0.614 | |
| 2eka | SAH | Diphthine synthase | / | 0.612 | |
| 2dek | SAH | Diphthine synthase | / | 0.603 | |
| 2pcm | SAH | Diphthine synthase | / | 0.603 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.590 | |
| 2emu | SAH | Diphthine synthase | / | 0.587 | |
| 2p2x | SAH | Diphthine synthase | / | 0.587 | |
| 2egl | SAH | Diphthine synthase | / | 0.582 | |
| 2owf | SAH | Diphthine synthase | / | 0.582 | |
| 2egs | SAH | Diphthine synthase | / | 0.580 | |
| 2e16 | SAH | Diphthine synthase | / | 0.579 | |
| 2owv | SAH | Diphthine synthase | / | 0.575 | |
| 2ehl | SAH | Diphthine synthase | / | 0.556 | |
| 2p6d | SAH | Diphthine synthase | / | 0.554 | |
| 2ejz | SAH | Diphthine synthase | / | 0.541 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.459 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.457 | |
| 3up5 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.456 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.455 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.454 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.453 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.450 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.450 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.450 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.450 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.450 | |
| 2b8l | 5HA | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.448 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.448 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.447 | |
| 3kc3 | MK2 | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.447 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.447 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.446 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.445 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.445 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.444 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.443 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.443 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.443 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.443 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.442 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.442 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.442 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.442 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.440 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.440 |