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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2e2b406Tyrosine-protein kinase ABL12.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2e2b406Tyrosine-protein kinase ABL12.7.10.21.000
2hznKINTyrosine-protein kinase ABL12.7.10.20.552
2hiw7MPTyrosine-protein kinase ABL12.7.10.20.542
2hyySTITyrosine-protein kinase ABL12.7.10.20.535
3hv6R39Mitogen-activated protein kinase 14/0.528
5hidB1ESerine/threonine-protein kinase B-raf2.7.11.10.523
3p7bP7BMitogen-activated protein kinase 14/0.515
3o8uBMUMitogen-activated protein kinase 14/0.496
2yisYISMitogen-activated protein kinase 14/0.492
1kv2B96Mitogen-activated protein kinase 14/0.480
3p7cP7CMitogen-activated protein kinase 14/0.480
3vhe42QVascular endothelial growth factor receptor 22.7.10.10.480
3p7aP7AMitogen-activated protein kinase 14/0.476
3uvr06FMitogen-activated protein kinase 14/0.470
1kv1BMUMitogen-activated protein kinase 14/0.466
3nwq2NCGag-Pol polyprotein3.4.23.160.465
4ugaH4BNitric oxide synthase oxygenase1.14.13.1650.464
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.461
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.458
4asdBAXVascular endothelial growth factor receptor 22.7.10.10.457
1wbsLI2Mitogen-activated protein kinase 14/0.456
3p5kP5KMitogen-activated protein kinase 14/0.456
3gcuR48Mitogen-activated protein kinase 14/0.454
3npcB96Mitogen-activated protein kinase 92.7.11.240.454
4hw764MMacrophage colony-stimulating factor 1 receptor2.7.10.10.454
3bgcLJHGag-Pol polyprotein3.4.23.160.452
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
4lwaQ13Nitric oxide synthase oxygenase1.14.13.1650.450
3ugc046Tyrosine-protein kinase JAK2/0.449
5ks72BACarnitine transport ATP-binding protein OpuCA3.6.3.320.448
3e9319BMitogen-activated protein kinase 14/0.447
3nu9478Gag-Pol polyprotein3.4.23.160.447
1difA85Gag-Pol polyprotein/0.446
4dtaADNAPH(2'')-Id/0.446
4ug7H4BNitric oxide synthase oxygenase1.14.13.1650.446
1ckpPVBCyclin-dependent kinase 22.7.11.220.445
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.445
3gvuSTIAbelson tyrosine-protein kinase 22.7.10.20.445
3t54ATPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.445
4r7iSTIMacrophage colony-stimulating factor 1 receptor2.7.10.10.445
2bpy3INGag-Pol polyprotein3.4.23.160.444
3lfbZ87Mitogen-activated protein kinase 14/0.443
3nxe2NCProtease/0.442
3qw2NADMyo-inositol-1-phosphate synthase (Ino1)/0.442
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.442
2qak1UNGag-Pol polyprotein3.4.23.160.441
4fkpLS5Cyclin-dependent kinase 22.7.11.220.441
4ug91EWNitric oxide synthase oxygenase1.14.13.1650.441
3juhANPCasein kinase II subunit alpha2.7.11.10.440
3mvhWFERAC-alpha serine/threonine-protein kinase2.7.11.10.440
3n7uNADFormate dehydrogenase, chloroplastic/mitochondrial/0.440
4h1m0YJProtein-tyrosine kinase 2-beta2.7.10.20.440