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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c475IDCasein kinase I isoform gamma-2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2c475IDCasein kinase I isoform gamma-2/1.000
4hgs15GCasein kinase I isoform gamma-32.7.11.10.513
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.502
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.501
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.488
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.485
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.483
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.479
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.478
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.475
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.473
2izsBRQCasein kinase I isoform gamma-32.7.11.10.472
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.470
4g160VMCasein kinase I isoform gamma-32.7.11.10.464
2c7xNRBCytochrome P450 monooxygenase PikC/0.460
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.456
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.455
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.455
2izt23DCasein kinase I isoform gamma-32.7.11.10.454
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.454
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.450
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.448
3t2zFADSulfide-quinone reductase/0.447
3tvuB37Acetyl-CoA carboxylase/0.446
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.444
3t2yFADSulfide-quinone reductase/0.443
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.443
3lltANPProtein serine/threonine kinase-1/0.442
2ath3EAPeroxisome proliferator-activated receptor gamma/0.441
2yaaATPDeath-associated protein kinase 2/0.441
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands/0.441
3p6mDSOCamphor 5-monooxygenase1.14.15.10.441
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.441
1bygSTUTyrosine-protein kinase CSK/0.440
3gc8B45Mitogen-activated protein kinase 112.7.11.240.440