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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2bt4CA23-dehydroquinate dehydratase4.2.1.10

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2bt4CA23-dehydroquinate dehydratase4.2.1.101.000
2cjfRP43-dehydroquinate dehydratase4.2.1.100.600
3n87N873-dehydroquinate dehydratase4.2.1.100.558
4b6s2HN3-dehydroquinate dehydratase4.2.1.100.535
2xb9XNW3-dehydroquinate dehydratase4.2.1.100.534
4b6r3DQ3-dehydroquinate dehydratase4.2.1.100.511
2xdaJPS3-dehydroquinate dehydratase4.2.1.100.480
1xddAAYIntegrin alpha-L/0.477
2wksCB63-dehydroquinate dehydratase4.2.1.100.472
3n76CA23-dehydroquinate dehydratase4.2.1.100.470
4f0e0RUPoly [ADP-ribose] polymerase 152.4.2.300.460
2xb8XNW3-dehydroquinate dehydratase4.2.1.100.457
4bf9FMNtRNA-dihydrouridine(16) synthase/0.457
4br0AU1Ectonucleoside triphosphate diphosphohydrolase 2/0.457
4l0oPLPCystathionine gamma-synthase2.5.1.480.454
4g8jTHMUridine phosphorylase/0.450
3tqxPLP2-amino-3-ketobutyrate coenzyme A ligase/0.446
3lm8VIBThiamine pyrophosphokinase2.7.6.20.444
3vx4ATPPutative ABC transporter, ATP-binding protein ComA/0.443
4c36ZO9cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2a0yDIHPurine nucleoside phosphorylase2.4.2.10.442
2y71CB63-dehydroquinate dehydratase4.2.1.100.441
3c35KAIGlutamate receptor ionotropic, kainate 1/0.440
3h0bB35Beta-secretase 13.4.23.460.440