sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2bc9 | GNP | Guanylate-binding protein 1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2bc9 | GNP | Guanylate-binding protein 1 | / | 1.000 | |
| 1f5n | GNP | Guanylate-binding protein 1 | / | 0.518 | |
| 2i51 | FMN | Pyridoxamine 5'-phosphate oxidase-related, FMN-binding | / | 0.507 | |
| 4idn | GNP | Atlastin-1 | 3.6.5 | 0.478 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.459 | |
| 4anb | YQY | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.458 | |
| 1hdg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.456 | |
| 1f8s | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.454 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.454 | |
| 2x6d | X6D | Aurora kinase A | 2.7.11.1 | 0.453 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.453 | |
| 4rcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.451 | |
| 3tri | NAP | Pyrroline-5-carboxylate reductase | / | 0.450 | |
| 1pn3 | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.449 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.449 | |
| 2ep7 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.448 | |
| 2g76 | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.448 | |
| 4oa9 | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.447 | |
| 1dnp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.446 | |
| 4nxx | GDP | Mitochondrial dynamics protein MID51 | / | 0.445 | |
| 3zrm | ZRM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.444 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.444 | |
| 4h4q | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.444 | |
| 1udc | UFM | UDP-glucose 4-epimerase | 5.1.3.2 | 0.443 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.443 | |
| 1os1 | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.442 | |
| 2ceo | T44 | Thyroxine-binding globulin | / | 0.442 | |
| 3a0t | ADP | Sensor histidine kinase | / | 0.442 | |
| 4c2u | ANP | DNA helicase | / | 0.442 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.442 | |
| 4jzy | FAD | Cryptochrome-1 | / | 0.442 | |
| 4xyb | NDP | Formate dehydrogenase | / | 0.442 | |
| 4ftk | H9K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.440 | |
| 2x9f | X9F | Ephrin type-B receptor 4 | 2.7.10.1 | 0.440 | |
| 4gu5 | FAD | Cryptochrome-1 | / | 0.440 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.440 |