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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2b5vNAPGlucose 1-dehydrogenase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2b5vNAPGlucose 1-dehydrogenase/1.000
2vwpNDPGlucose 1-dehydrogenase/0.647
2vwqNAPGlucose 1-dehydrogenase/0.563
1pl8NADSorbitol dehydrogenase1.1.1.140.482
2vwhNAPGlucose 1-dehydrogenase/0.482
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.466
3r1sX73Cyclin-dependent kinase 22.7.11.220.464
3t5iSER_SER_CMT_FARRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.461
4dlj6RGMitogen-activated protein kinase 14/0.460
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.460
3dpd41APhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
3nmhPYVAbscisic acid receptor PYL2/0.456
3mvl38PMitogen-activated protein kinase 14/0.455
1k6tXN1Gag-Pol polyprotein3.4.23.160.454
3os33OSDual specificity mitogen-activated protein kinase kinase 12.7.12.20.454
4h4xFADBiphenyl dioxygenase ferredoxin reductase subunit/0.453
3el01UNGag-Pol polyprotein3.4.23.160.451
1meiMOAInosine-5'-monophosphate dehydrogenase/0.450
1qnfFADDeoxyribodipyrimidine photo-lyase4.1.99.30.450
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.449
4ek610KCyclin-dependent kinase 22.7.11.220.449
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.447
1me8RVPInosine-5'-monophosphate dehydrogenase/0.445
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.445
1hpoUNIGag-Pol polyprotein3.4.23.160.444
1me7RVPInosine-5'-monophosphate dehydrogenase/0.443
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
1e8wQUEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
1k6cMK1Gag-Pol polyprotein3.4.23.160.442
4cdmFADDeoxyribodipyrimidine photolyase/0.442
2iw84SPCyclin-dependent kinase 22.7.11.220.441
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.441
3r7uX96Cyclin-dependent kinase 22.7.11.220.441
2qnqQN3Gag-Pol polyprotein3.4.23.160.440