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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1z8aNAPAldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1z8aNAPAldose reductase1.1.1.211.000
1x98NAPAldose reductase1.1.1.210.744
1x96NAPAldose reductase1.1.1.210.721
2acqNAPAldose reductase1.1.1.210.716
2iq0NAPAldose reductase1.1.1.210.705
1adsNAPAldose reductase1.1.1.210.684
2acsNAPAldose reductase1.1.1.210.635
3v36NAPAldose reductase1.1.1.210.633
1az2NAPAldose reductase1.1.1.210.618
3q65NAPAldose reductase1.1.1.210.618
2pf8NDPAldose reductase1.1.1.210.609
2pevNDPAldose reductase1.1.1.210.603
2j8tNAPAldose reductase1.1.1.210.601
2pfhNDPAldose reductase1.1.1.210.600
1ah4NAPAldose reductase1.1.1.210.596
2acuNAPAldose reductase1.1.1.210.592
3qkzNAPAldose reductase-related protein 11.1.1.210.547
3o3rNAPAldose reductase-related protein 11.1.1.210.529
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.517
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.513
1c9wNAPAldose reductase-related protein 2/0.484
3h7rNAPAldo-keto reductase family 4 member C8/0.484
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.479
4xo7NAPAldo-keto reductase family 1 member C2/0.479
2hdjNDPAldo-keto reductase family 1 member C2/0.469
2hejNDPAldo-keto reductase family 1 member C211.1.10.469
4g5dNDPProstaglandin F synthase1.1.1.1880.466
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.450
1zgdNAPChalcone reductase/0.447
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.446
4jtqNAPAldo-keto reductase family 1 member C2/0.446
1s1rNAPAldo-keto reductase family 1 member C3/0.444
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.443
1lqaNDPProtein tas/0.442