sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1vea | HBN | Hut operon positive regulatory protein |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1vea | HBN | Hut operon positive regulatory protein | / | 1.000 | |
| 4mf0 | 29Z | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.467 | |
| 1phh | FAD | p-hydroxybenzoate hydroxylase | / | 0.464 | |
| 2e9v | 85A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.464 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.464 | |
| 1rw8 | 580 | TGF-beta receptor type-1 | 2.7.11.30 | 0.463 | |
| 4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.463 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 2h12 | CMX | Citrate synthase | / | 0.448 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.447 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.447 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.446 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.445 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.444 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.444 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.444 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.444 | |
| 4n3c | UD1 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.444 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.443 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.443 | |
| 2bxm | IMN | Serum albumin | / | 0.442 | |
| 2e5a | LAQ | Lipoyltransferase 1, mitochondrial | 2.3.1 | 0.442 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.442 | |
| 3gb4 | D3M | DdmC | / | 0.441 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.440 | |
| 4kb8 | 1QO | Casein kinase I isoform delta | 2.7.11.1 | 0.440 | |
| 5dp2 | NAP | CurF | / | 0.440 |