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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.59

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.591.000
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.740
1n4qLYS_CYS_VAL_ILE_LEUGeranylgeranyl transferase type-1 subunit beta2.5.1.590.484
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.469
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.469
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.468
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.466
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.463
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.463
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.462
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.460
1s63778Protein farnesyltransferase subunit beta2.5.1.580.458
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.457
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.454
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.454
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.451
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.450
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.449
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.442