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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1mduATPActin, alpha skeletal muscle

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1mduATPActin, alpha skeletal muscle/1.000
2q36ATPActin, alpha skeletal muscle/0.598
3m1fATPActin, alpha skeletal muscle/0.592
4k42ADPActin, alpha skeletal muscle/0.589
1h1vATPActin, alpha skeletal muscle/0.578
1rgiATPActin, alpha skeletal muscle/0.575
4pkiATPActin, alpha skeletal muscle/0.570
3ffkATPActin, alpha skeletal muscle/0.564
4pkgATPActin, alpha skeletal muscle/0.562
3tu5ATPActin, alpha skeletal muscle/0.561
4pkhADPActin, alpha skeletal muscle/0.553
1c0fATPMajor actin/0.550
1lotATPActin, alpha skeletal muscle/0.543
1kxpATPActin, alpha skeletal muscle/0.542
5ce3ATPActin/0.541
3m6gATPActin, alpha skeletal muscle/0.525
1s22ATPActin, alpha skeletal muscle/0.524
1nmdATPMajor actin/0.522
1t44ATPActin, alpha skeletal muscle/0.514
1ijjATPActin, alpha skeletal muscle/0.512
4cbxATPActin-2/0.512
4pl8ATPActin, alpha skeletal muscle/0.509
2v51ATPActin, alpha skeletal muscle/0.508
4jhdANPActin-5C/0.508
3mn9ATPActin-5C/0.507
2q97ATPActin, alpha skeletal muscle/0.505
3u9dATPActin, alpha skeletal muscle/0.504
3w3dATPActin, gamma-enteric smooth muscle/0.504
4ci6ATPActin/0.491
4m63ATPActin-5C/0.489
3mn6ATPActin-5C/0.478
1nm1ATPMajor actin/0.477
3a5oATPMajor actin/0.472
2a41ATPActin, alpha skeletal muscle/0.467
3u4lATPActin, cytoplasmic 1/0.467
3chwATPMajor actin/0.452
1rfqATPActin, alpha skeletal muscle/0.450
3el2ATPActin-5C/0.442